Drug resistant epilepsy. Epilepsy and recurrent seizures
Conditions
Interventions
Intervention 1: Intervention group: Receiving a 20 mg dose of atorvastatin. Intervention 2: Intervention group: Receiving a 40 mg dose of atorvastatin. Intervention 3: Control group: Not receiving ato
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients over 18 years old Patients with drug-resistant epilepsy who experience at least 3 seizures per month. According to the latest definition by the International League Against Epilepsy (ILAE), drug-resistant epilepsy is defined as the failure of at least two appropriate treatments at adequate doses and tolerable levels (whether as monotherapy or combination therapy) to achieve a sustained seizure-free period.
Exclusion criteria
Exclusion criteria: History of prior statin use Presence of cardiovascular diseases Seizures occurring post-stroke (post-stroke seizures) Liver or kidney diseases Pregnancy and breastfeeding History of cancer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Seizure frequency per month. Timepoint: At the beginning of the study and after 12 weeks. Method of measurement: Questioning the patient.;Changes in EEG pattern. Timepoint: At the beginning of the study and after 12 weeks. Method of measurement: EEG. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAbbas Tafakhori
Tehran University of Medical Sciences
Outcome results
None listed