Comparison of fluid therapy methods in patients with sepsis: A clinical trial in the intensive care unit of Al-Zahra Hospital

Comparison of two methods of routine fluid therapy and targeted fluid therapy based on peripheral perfusion index in patients with sepsis hospitalized in the intensive care unit of Al-Zahra Hospital: a randomized clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240804062637N1

Enrollment

Registered

2024-08-16

Start date

2024-08-22

Completion date

Unknown

Last updated

2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis. Other sepsis

Interventions

Intervention 1: Control group: Control group: All selected patients will be treated for sepsis based on standard guideline recommendations. According to these guidelines, 30 mL/kg of lactated Ringer's

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with sepsis hospitalized in the intensive care unit

Exclusion criteria

Exclusion criteria: Inaccessible peripheral perfusion

Design outcomes

Primary

Measure	Time frame
Prevalence of peripheral hypoperfusion among the study groups. Timepoint: Every 30 seconds for 5 minutes daily over a span of seven days. Method of measurement: Pulse oximeter.	—

Secondary

Measure	Time frame
Blood lactate level. Timepoint: Between 6 and 24 hours after sepsis diagnosis. Method of measurement: Blood sample.;Mean arterial pressure. Timepoint: Between 6 and 24 hours after sepsis diagnosis. Method of measurement: Intensive care monitoring device.;Serum cystatin C level. Timepoint: Between 6 and 24 hours after sepsis diagnosis. Method of measurement: Blood sample.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSara Mousavi

Esfahan University of Medical Sciences

s.mousavi@pharm.mui.ac.ir+98 31 3792 7072

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026