Comparison of pre operative ketamine, lidocaine and magnesium cocktail versus morphine for management of postoperative pain in opium addict patients

Comparison of pre operative ketamine, lidocaine and magnesium (KLM) cocktail versus morphine for management of distal radius fracture surgery postoperative pain in opium addict patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240803062628N1

Enrollment

Registered

2024-11-09

Start date

2023-09-23

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Management of postoperative pain in opium addicted patients.

Interventions

Intervention 1: Intervention group: received 1.5mg/Kg IV lidocaine (Caspian Co.), 30mg/Kg IV magnesium (Pastor Ins.) and 0.3mg/Kg IV Ketamine (Exir Co.) diluted in 50cc normal saline 0.9% in 15 minute

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Consent to participate in the study Distal radius fracture confirmed by radiologic study Opium addiction history (At least 1gram per day to 5 gram per day) American Society of Anesthesiologists Class I,II

Exclusion criteria

Exclusion criteria: Surgery duration more than 2 hours Bleeding during operation leading to transfusion Hemodynamic instability during operation leading to utilizing medicine for controlling blood pressure History of cardiovascular diseases

Design outcomes

Primary

Measure	Time frame
Postoperative pain using visual analogue scale (VAS). Timepoint: In recovery unit and 3, 6, and 12 hours after surgery. Method of measurement: Evaluation of nurses of recovery unit and ward based on VAS score (0-10).	—

Secondary

Measure	Time frame
Side effects of analgesics (Shivering, nausea, vomiting). Timepoint: In recovery unit. Method of measurement: Based on evaluation of anesthesia nurse (Qualitative).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHosein Niazi

Shahid Beheshti University of Medical Sciences

niazihossein091@gmail.com+98 21 8896 5109

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026