The Effect of Vitamin E Administration on the Improvement of Pneumonia in Children Aged 2-12 Years

Evaluation of the Effect of Vitamin E prescription on the Improvement of Pneumonia in 2-12 Years Old Children

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240730062595N1

Enrollment

Registered

2024-10-14

Start date

2024-10-22

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Pneumonia. Condition 2: Pneumonia. Streptococcus pneumoniae as the cause of diseases classified elsewhere Mycoplasma pneumoniae [M. pneumoniae] as the cause of diseases classified elsewhere

Interventions

Intervention 1: Vitamin E:Chemical Composition: Alpha-tocopheryl acetate Concentration: 100 International Units (IU) per milliliter of syrup Administration Method: Vitamin E is administered orally in

Eligibility

Sex/Gender

All

Age

2 Years to 12 Years

Inclusion criteria

Inclusion criteria: Children aged 2-12 years with pneumonia, excluding those with conditions such as cystic fibrosis or severe malnutrition.

Exclusion criteria

Exclusion criteria: Lack of consent from the patient or parents, worsening of pneumonia, and the need for mechanical ventilation.

Design outcomes

Primary

Measure	Time frame
Pneumonia Recovery: Pneumonia recovery is evaluated based on clinical and physical symptoms, including fever resolution, reduction in tachypnea, reduction in respiratory distress, reduction in cough, and improvement in physical examination signs such as decreased or absent crackles (rales) and wheezing. Timepoint: At baseline (upon admission). 24 hours after the start of treatment. 48 hours after the start of treatment. 72 hours after the start of treatment. 7 days after the start of treatment. Method of measurement: Fever Resolution: Measuring body temperature using a thermometer.Reduction in Tachypnea: Counting the number of breaths per minute.Reduction in Respiratory Distress: Observing and recording symptoms of respiratory distress, such as intercostal and subcostal retractions.Reduction in Cough: Assessing the severity and frequency of cough based on parental reports and clinical observations.Physical Examination Signs: Checking for the presence or absence of crackles (rales) and wheezing during clinical examination by a physician.	—

Measure

Time frame

Pneumonia Recovery: Pneumonia recovery is evaluated based on clinical and physical symptoms, including fever resolution, reduction in tachypnea, reduction in respiratory distress, reduction in cough, and improvement in physical examination signs such as decreased or absent crackles (rales) and wheezing. Timepoint: At baseline (upon admission). 24 hours after the start of treatment. 48 hours after the start of treatment. 72 hours after the start of treatment. 7 days after the start of treatment. Method of measurement: Fever Resolution: Measuring body temperature using a thermometer.Reduction in Tachypnea: Counting the number of breaths per minute.Reduction in Respiratory Distress: Observing and recording symptoms of respiratory distress, such as intercostal and subcostal retractions.Reduction in Cough: Assessing the severity and frequency of cough based on parental reports and clinical observations.Physical Examination Signs: Checking for the presence or absence of crackles (rales) and wheezing during clinical examination by a physician.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarhad heidarian

Mashhad University of Medical Sciences

Fathip4001@mums.ac.ir+98 915 471 8148

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026