Investigating the effect of vancomycin loading dose in diabetic foot patients. Diabetes mellitus due to underlying condition
Conditions
Interventions
Intervention 1: Forty drug candidate patients receiving Laoding dose with a dose (20-35 mg/kg) of 25 mg/kg vancomycin (vancomycin injection vial of Dena Pharmaceutical Company) (maximum 2 grams, even
Sponsors
Yazd University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Diabetic patients over 18 years of age with purulent drainage, swelling, and redness in the leg area below the knee who are admitted to the infectious department of Shahid Sadoughi Hospital in Yazd and are candidates for treatment with vancomycin injection form to treat diabetic foot infection Receive vancomycin for at least 7 days
Exclusion criteria
Exclusion criteria: history of sensitivity to vancomycin BMI=30 vancomycin-resistant microorganism in the antibiogram Pregnancy, breastfeeding under hemodialysis, peritonealdialysis, or CCRT Patients who have had effective antibiotic therapy with an effective dose and treatment period during the last 48 hours are excluded from the study unless Have evidence of previous antibiotic treatment failure, or antibiotic resistance to previous cases. Patients who are treated with antibiotics for other reasons Patients who are treated with topical antibiotic on diabetic foot ulcer Receiving vancomycin for surgical prophylaxis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of clinical outcomes in patients with diabetic foot infection in two groups receiving vancomycin loading dose and the group not receiving it. Timepoint: At the beginning of the study and during the study for up to 7 days. Method of measurement: Examination of clinical outcome based on clinical manifestations.;Comparison of laboratory results in patients with diabetic foot infection in two groups receiving vancomycin loading dose and the group not receiving it. Timepoint: At the beginning of the study and during the study up to 7 days. Method of measurement: Examining laboratory results based on inflammatory factors, Erythrocyte Sedimentation rate and C-reactive protein and white blood cell count.;Comparison of the occurrence of acute kidney injury in patients with diabetic foot infection in two groups receiving vancomycin loading dose and the group not receiving it. Timepoint: At the beginning of the study and during the study up to 7 days. Method of measurement: Assessment of acute kidney injury based on serum creatinine and urine volume. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNazanin Nematelahi
Yazd University of Medical Sciences
Outcome results
None listed