Investigating the effect of the active form of fulate on homocysteine

Investigating the effect of the active form of folate compared to folic acid on homocysteine level inpostmenopausal women with metabolic syndrome

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240722062513N1

Enrollment

Registered

2024-08-16

Start date

2024-08-29

Completion date

Unknown

Last updated

2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metabolic syndrome, hyperhomocysteinemia.

Interventions

Intervention 1: First intervention group: 1 mg of the active form of folate daily for 4 months. Intervention 2: Second intervention group: 1 mg of folic acid daily for 4 months.

Eligibility

Sex/Gender

Female

Age

53 Years to 70 Years

Inclusion criteria

Inclusion criteria: Female gender Age between 53 to 70 At least 2 years have passed since menopause Having criteria for metabolic syndrome

Exclusion criteria

Exclusion criteria: History of miocardial infarction Drinking alcohol or smoking

Design outcomes

Primary

Measure	Time frame
Serum homocysteine ??level. Timepoint: Measurement of serum homocysteine ??level before the intervention and 4 months after taking the drug. Method of measurement: Blood biochemistry test.	—

Secondary

Measure	Time frame
Cholesterol. Timepoint: Cholesterol level measurement before the intervention and 4 months after the intervention. Method of measurement: blood test.;High-density lipoprotein. Timepoint: Measurement before the intervention and 4 months after the intervention. Method of measurement: blood test.;Low-density lipoprotein. Timepoint: Measurement before the intervention and 4 months after the intervention. Method of measurement: blood test.;Triglyceride. Timepoint: Measurement before the intervention and 4 months after the intervention. Method of measurement: blood test.	—

Measure

Time frame

Cholesterol. Timepoint: Cholesterol level measurement before the intervention and 4 months after the intervention. Method of measurement: blood test.;High-density lipoprotein. Timepoint: Measurement before the intervention and 4 months after the intervention. Method of measurement: blood test.;Low-density lipoprotein. Timepoint: Measurement before the intervention and 4 months after the intervention. Method of measurement: blood test.;Triglyceride. Timepoint: Measurement before the intervention and 4 months after the intervention. Method of measurement: blood test.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Abed

Tehran University of Medical Sciences

M-Abed@student.tums.ac.ir+98 936 284 5781

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026