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Effect of Dino® on voice changes after thyroid surgery

Evaluation of the effect of the supplement product, Dino®, on the improvement of dysphonia as a complication of thyroidectomy surgery; a randomized controlled trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240721062502N1
Enrollment
80
Registered
2025-01-06
Start date
2024-10-22
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dysphonia. Dysphonia

Interventions

Intervention 1: Intervention group: Treating with the supplement Dino® tablets containing vitamins B1 (thiamin), B6 (Pyridoxin), B12 (Cobalamin), and B9 (Folic acid) along with alpha lipoic acid at 10

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients older than 18 years of age Patients who performed thyroidectomy surgery regardless of its clinical indication Patients showing the complication of dysphonia after a 2-week follow-up after surgery Patients having consent to taking part in the study

Exclusion criteria

Exclusion criteria: Patients with known laryngeal nerve damage during operation or malignant nerve involvement Patients with a history of gastroesophageal reflux disease (GERD) Patients with previous neck surgery Patients who frequently experience hypoglycemia following use of antidiabetic agents Patients with known vocal cord dysfunction Patients with hearing or voice problems Patients with known allergy to any of the components of the product Patients younger than 18 years of age Pregnant and lactating women Patients unwilling to take part in the study

Design outcomes

Primary

MeasureTime frame
Change in the extent of dysphonia. Timepoint: Evaluation of dysphonia will be performed at the start of the study (before the intervention) and 2 weeks (14 days) after medication therapy. Method of measurement: Voice Handicap Index-10 questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDena Firouzabadi

Shiraz University of Medical Sciences

denaf9@yahoo.com+98 71 3242 4128

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026