Cutaneous listeriosis. Cutaneous listeriosis
Conditions
Interventions
Intervention 1: Intervention group: Standard protocol (local injection of glucantim) plus topical application of cotton extract. Intervention 2: Control group: Standard protocol (local injection of
Sponsors
Sabzevar University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients aged 18-65 with confirmed cutaneous leishmaniasis, referred to the city's Leishmaniasis Reference Centers (positive blood smear, eligible for standard topical treatment, and registered in the National Leishmaniasis System), presenting with at least one skin ulcer between 1 and 4 cm.
Exclusion criteria
Exclusion criteria: Systemic treatment criteria include: lesions on sensitive facial areas (eyelids, ears, nose, lips, mouth); five or more lesions; lesion diameter exceeding 3 cm; atypical forms (e.g., sporotrichoid, scarlet fever); lesions on joints; immunocompromising conditions or immunosuppressant use; pregnancy or breastfeeding; pre-existing skin conditions (e.g., eczema, psoriasis, lupus, pemphigus, fungal lesions); mental disorders or severe mental illness (e.g., depression, dementia); facial or ear lesions; lesion infection; or concurrent herbal treatment for the lesion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Wound size reduction (length, width, and area). Timepoint: Every two weeks. Method of measurement: Ruler. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain, itching, and redness. Timepoint: Before and end of the study. Method of measurement: VAS. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFereshteh Ghorat
Sabzevar University of Medical Sciences
Outcome results
None listed