Condition 1: Cancer. Condition 2: Chemotherapy induced peripheral neuropathy (CIPN). Malignant (primary) neoplasm, unspecified Drug-induced polyneuropathy
Conditions
Interventions
Intervention 1: Intervention group: In the intervention group, 1 cc of garlic oil is applied twice daily for 6 weeks to the soles of the feet and the backs of the hands and feet, from the wrists to th
Sponsors
Sabzevar University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Cancer patients with neuropathy, following chemotherapy, approved by the oncologist, and a pain score greater than 1 based on the McGill Pain Questionnaire-2 (SF-MPQ-2). The use of one of the following chemotherapy regimens that cause neuropathy, including taxane group drugs in weekly, 2-week, or 3-week regimens, such as the AC-Taxol, TCH, TC, or TAC regimens.
Exclusion criteria
Exclusion criteria: Diagnosis of depression, peripheral vascular disease Use of other drugs effective in treating neuropathy, such as gabapentin, pregabalin, or duloxetine diabetes or alcohol abuse Pregnancy or breastfeeding Severe underlying condition Allergy to garlic oil or a placebo
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain intensity. Timepoint: At baseline, at the end of each week and at the end of the sixth week. Method of measurement: Brief Pain Inventory - Short form (BPI-SF) questionnaire.;Functional performance. Timepoint: At baseline, at the end of each week and at the end of the sixth week. Method of measurement: Brief Pain Inventory - Short form (BPI-SF) questionnaire.;Neuropathy severity. Timepoint: At baseline, at the end of each week and at the end of the sixth week. Method of measurement: European Organization for Research and Treatment of Cancer Quality of Life Questionnaire—Chemotherapy-Induced Peripheral Neuropathy Module (EORTC QLQ-CIPN20) questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShamim Shahrestani
Sabzevar University of Medical Sciences
Outcome results
None listed