Rheumatoid Arthritis. Rheumatoid arthritis with rheumatoid factor
Conditions
Interventions
Intervention 1: Intervention group: Sesame meal supplement + MIND diet. Sesame meal supplement in the form of pressed tablets is prepared from powdered sesame meal in the phar
Sponsors
Yazd University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Suffering from rheumatoid arthritis as diagnosed by a doctor
Exclusion criteria
Exclusion criteria: Unwillingness to participate in the study Pregnancy and breastfeeding Smoking and alcohol consumption Use of oral contraceptives Suffering from chronic diseases including kidney, respiratory, heart diseases, uncontrolled diabetes (according to the doctor's opinion and diagnosis) and diseases related to weight change. Use of estrogenic and hormonal drugs Use of weight loss drugs in the last 3 months Following a special diet in the last month Recent surgery within the last 6 months Consuming supplements containing sesame compounds or sesame flour before starting the intervention
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total antioxidant capacity. Timepoint: At the beginning of the study (before the start of the intervention) and at the end of the study (after three months of the intervention). Method of measurement: Using patients' serum and total antioxidant capacity measurement kit.;Nitric oxide. Timepoint: At the beginning of the study (before the start of the intervention) and at the end of the study (after three months of the intervention). Method of measurement: Using patients' serum and nitric oxide measurement kit.;CD40 gene expression. Timepoint: At the beginning of the study (before the start of the intervention) and at the end of the study (after three months of the intervention). Method of measurement: Gene expression by REALTIME method.;Malondialdehyde. Timepoint: At the beginning of the study (before the start of the intervention) and at the end of the study (after three months of the intervention). Method of measurement: Using patients' serum and Malondialdehyde measurement kit.;C reactive protein. Timepoint: At the beginning of the study (before the start of the intervention) and at the end of the study (after three months of the intervention). Method of measurement: Using patients' serum and C reactive protein measurement kit.;Disease Activity Score in 28 Joints (DAS28). Timepoint: At the beginning of the study (before the start of the intervention) and at the end of the study (after three months of the intervention). Method of measurement: Doctor-supervised questionnaire.;STAT4 gene expression. Timepoint: At the beginning of the study (before the start of the intervention) and at the end of the study (after three months of the intervention). Method of measurement: Gene expression by REALTIME method.;Fatigue. Timepoint: At the beginning of the study (before the start of the intervention) and at the end of the study (after three months of the intervention). Method of measurement: Smiths Fatigue Questionnaire (MFI).;Sleep quality. Timepoint: At the beginning of the | — |
Secondary
| Measure | Time frame |
|---|---|
| Body mass index. Timepoint: At the beginning of the study (before the start of the intervention) and at the end of the study. Method of measurement: Using height and weight and formula.;Nutrient intake. Timepoint: at the beginning of the study on 3 days of the week (one day on the weekend, two days during the week) and at the end of the study on 3 days of the week (one day on the weekend, two days during the week). Method of measurement: 24 hour dietary recall questionnaire.;Blood pressure. Timepoint: At the beginning of the study (before the start of the intervention) and at the end of the study. Method of measurement: Omron digital blood pressure monitor. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahdieh Hosseinzadeh
Yazd University of Medical Sciences
Outcome results
None listed