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Effect of oral melatonin on chronic central serous chorioretinopathy

Evaluation of the effect of oral melatonin on the central macular thickness in patients with chronic Central serous chorioretinopathy (CSCR)

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240710062383N1
Enrollment
20
Registered
2025-07-03
Start date
2025-07-23
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Central Serous Chorioretinopathy. Central serous chorioretinopathy

Interventions

Intervention group: Patients in this group will be treated with 3 mg oral melatonin tablets (manufactured by Razak Laboratories) every 8 hours for 1 month..

Sponsors

Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Chronic CSCR Lack of improvement in signs and symptoms of the disease at least 4 months after the incidence

Exclusion criteria

Exclusion criteria: History of Retinal MPC, PRP, or PDT History of intraocular injections of Anti-VEGF History of any ocular surgery other than an uneventful cataract surgery more than 6 months ago History of any other ocular disease such as uveitis, glaucoma, hypertensive retinopathy, diabetic retinopathy, CNV, or KCN Having visually significant cataracts Use of any immunomodulator medication such as corticosteroids Taking antioxidant medications such as vitamin E Use of any medication with adverse effects on the macula, such as Fingolimod and Deferoxamine Being under Chemotherapy History of any systemic condition needing medical treatment, such as an autoimmune disease Lack of consent to participate in the study

Design outcomes

Primary

MeasureTime frame
Central macular thickness. Timepoint: Before the intervention and 1 month after the intervention. Method of measurement: Macular Optical Coherence Tomography (OCT).;Best-corrected visual acuity. Timepoint: Before the intervention and 1 month after the intervention. Method of measurement: 6-meter E-Chart.

Secondary

MeasureTime frame
Adverse effects. Timepoint: Weekly visits from the start of treatment until 1 month. Method of measurement: Physical examinations and History taking.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarzam Alizadeh

Tabriz University of Medical Sciences

farzam.alizadeh@yahoo.com+98 41 3655 1332

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026