Chronic cough. Cough
Conditions
Interventions
Intervention 1: Intervention group: Patients in the intervention group will consume 5 cc every 8 hours of a herbal syrup (Fran) containing eucalyptus, thyme, Mallow, green tea, Hollyhocks, ginger, hys
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Adults aged 18-80 years Visiting a physician for unexplained cough (ie, no associated diagnosis) or persistent cough (eg, cough that has persisted after treatment for associated diagnoses of asthma, rhinitis, gastroesophageal reflux disease, use of angiotensin-converting enzyme inhibitors) Informed consent
Exclusion criteria
Exclusion criteria: Allergy to eucalyptus, thyme, Mallow, green tea, Hollyhocks, ginger, hyssop, Echinacea angustifolia, garlic, Marrubium and peppermint Cough with infectious sputum Pregnancy/breastfeeding Significant mental or neurological disorder Patients with the possibility of surgery in the next two weeks Patients with a history of gastrointestinal bleeding Diabetic patients with uncontrollable blood sugar in the last three months
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Cough-related quality of life with LCQ score. The sub-domains of quality of life related to physical, psychological and social cough. Total cessation of cough on the third and twentieth days after starting treatment with medicine or placebo. Incidence of re-visit to physician and/or hospitalization for possible worsening of disease and occurrence of adverse events within 20 days after randomization. Incidence of adverse events within 20 days after randomization. Timepoint: Baseline, third and twentieth days. Method of measurement: Leicester Cough Questionnaire. | — |
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is cough-related quality of life at 20 days after randomization. The validated score of the Leicester cough questionnaire will be used to evaluate the effect of the drug on the patients' quality of life (the mean difference between the arms measured 20 days after randomization). Total LCQ points will be calculated. The LCQ is also suitable for recording longitudinal improvements in cough and cough-related recovery. Timepoint: Baseline, third and twentieth days. Method of measurement: Leicester Cough Questionnaire (LCQ). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahnaz Khanavi
Tehran University of Medical Sciences
Outcome results
None listed