Bisoprolol vs, standard therapy; managing Hypertension in adults

The effect of bisoprolol monotherapy for the management of hypertension of otherwise healthy adults younger than 60 years compared to the standard therapy with valsartanamlodipine

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240701062299N2

Enrollment

Registered

2025-01-28

Start date

2022-08-01

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension.

Interventions

Intervention 1: Intervention group: bisoprolol monotherapy. Intervention 2: Control group: valsartan-amlodipine.

Eligibility

Sex/Gender

All

Age

16 Years to 60 Years

Inclusion criteria

Inclusion criteria: age between 18 and 60 years stage one or two hypertension recently diagnosed

Exclusion criteria

Exclusion criteria: any contraindications to beta-blockers, CCBs, or ARBs (e.g. symptomatic bradycardia, asthma, advanced renal failure, serum potassium > 5.5 mEq/L, severe edema of the lower extremities, etc.), associated complications that suggest the use of a specific agent (e.g., diabetes, heart failure, CKD, etc.), They will have extremely high blood pressure (SBP>= 180 and/or DBP>= 110), and the use of other medications that interact with beta-blockers, CCBs, or ARBs.

Design outcomes

Primary

Measure	Time frame
Blood pressure control. Timepoint: Q: From the start of the study, patients will be followed up on a weekly basis with phone calls (by experienced medical staff with sufficient knowledge about hypertension and its complications) to assess their blood pressure levels (and assess the need to adjust the dose, or change in medications to prevent any disease) and after 2 months, secondary ABPM will be performed for all participants to help us in the analysis. and help analyze the data accurately and discuss the results. Method of measurement: Q: From the start of the study, patients will be followed up on a weekly basis with phone calls (by experienced medical staff with sufficient knowledge about hypertension and its complications) to assess their blood pressure levels (and assess the need to adjust the dose, or change in medications to prevent any disease) and after 2 months, secondary ABPM will be performed for all participants to help us in the analysis. and help analyze the data accurately and discuss the results.	—

Measure

Time frame

Blood pressure control. Timepoint: Q: From the start of the study, patients will be followed up on a weekly basis with phone calls (by experienced medical staff with sufficient knowledge about hypertension and its complications) to assess their blood pressure levels (and assess the need to adjust the dose, or change in medications to prevent any disease) and after 2 months, secondary ABPM will be performed for all participants to help us in the analysis. and help analyze the data accurately and discuss the results. Method of measurement: Q: From the start of the study, patients will be followed up on a weekly basis with phone calls (by experienced medical staff with sufficient knowledge about hypertension and its complications) to assess their blood pressure levels (and assess the need to adjust the dose, or change in medications to prevent any disease) and after 2 months, secondary ABPM will be performed for all participants to help us in the analysis. and help analyze the data accurately and discuss the results.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactJavad Kojuri

Shiraz University of Medical Sciences

kojurij@yahoo.com+98 71 3735 5093

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026