GI Metastatic Cancer. Personal history of malignant neoplasm
Conditions
Interventions
Intervention 1: Intervention group: Take one probiotic capsule (500 mg) containing casei, lactobacillus acidophilus, lactobacillus rhamnosus, lactobacillus bulgaricus, bifidobacterium breve, bifidobac
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 65-18 years old with metastatic GI cancer undergoing chemotherapy No lactose intolerance Did not have any symptoms of diarrhea, constipation, nausea, vomiting, or mucositis before receiving chemotherapy, Functional status 0 or 1 according to ECOG (Eastern Cooperative Oncology Group)
Exclusion criteria
Exclusion criteria: Reluctance of the patient to participate in the study Description of underlying diseases including IBD \History of Colectomy Taking any antibiotic or other drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Examination of gastrointestinal symptoms: examination of changes in the severity of symptoms up to three chemotherapy courses (equivalent to 3 months) compared to zero time. Timepoint: Zero time & 3 months later. Method of measurement: The severity of diarrhea is described using the CTCAE Common Terms for Adverse Events criteria (NCI, National Cancer Institute). The severity of mucositis according to the CTCAE criteria.The type and severity of constipation based on the criteria (BRISTOL BSFS).;Examining inflammatory factors and tumor markers: Examining the changes three and six months after the intervention compared to zero time. Timepoint: Zero time, 3 and 6 months later. Method of measurement: laboratory evaluation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNiusha Nosrati
Shahid Beheshti University of Medical Sciences
Outcome results
None listed