Ovarian Hyperstimulation Syndrom. Hyperstimulation of ovaries
Conditions
Interventions
Intervention 1: Intervention group 1: Letrozole tablet 2.5 mg daily from the day of egg retrieval for 7 days. Intervention 2: Intervention group 2:Cetrolix acetate 0.25 mg subcutaneous ampoule from th
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 35 Years
Inclusion criteria
Inclusion criteria: Age of 20 to 35 years old BMI 18 to 29 kg/m2 AMH level more than 4ng/ml The number of antral follicles (AFC) in each ovary more than 12, confirmed by transvaginal ultrasound Serum level of estradiol (E2) more than 4000 pg/ml on the trigger day The number of punctured follicles more than 15 per ovary (follicular diameter of 14 mm on the day of egg retrieval)
Exclusion criteria
Exclusion criteria: Contraindications for use of letrozole or cetrolix acetate include severe liver and kidney dysfunction Women with estradiol (E2) level less than 4000 pg/ml in trigger day
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ovarian Hyperstimulation Syndrom (OHSS). Timepoint: As soon as the first clinical symptoms appear, the third day and the seventh day after trigger injection. Method of measurement: Clinical signs.;Serum Hematocrit level. Timepoint: On the day of trigger injection, and then on the third and seventh day after trigger injection. Method of measurement: CBC lab test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMina Ghorbani
Iran University of Medical Sciences
Outcome results
None listed