Cardiac surgeries including coronary artery bypass surgery with a pump, valve replacement surgery, and valve repair surgery.
Conditions
Interventions
Intervention 1: Intervention group: 0.5 mcg/kg/hr of dexmedetomidine infusion, midazolam 0.1-0.2 mg/kg/hr, and sufentanil: 3-5 mcg /kg/hr infusion according to patient situation. Intervention 2: Contr
Sponsors
Gorgan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients aged between 18-65 years both sexes male and female Patients under one of these surgery (pump coronary artery bypass surgery- valvular replacement surgery- valvular repair surgery) Informed consent to participate in the study
Exclusion criteria
Exclusion criteria: Patient with one of these diseases (serious coagulopathy- inflammatory diseases- immunosuppressive and immunomodulatory agents(DMARDs)- with history of arrhythmia- with chronic renal failure- Psychiatric diseases- with history of seizure- with history of rheumatic disorders) Patient uses these medicines (steroids- non-steroidal anti-inflammatory drugs (NSAD) except ASA < ?? mg/day- thrombolytic agent) Patient with more the one surgical procedure at the same time. Alcoholic patient Patient need more than one valve repair
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The amount of change in hemodynamic responses (heart rate, blood pressure, mean arterial pressure). Timepoint: Before and after surgery. Method of measurement: electrocardiogram to measure the heart rate and rhythm monitoring of non-invasive blood pressure, and end-tidal carbon dioxide (capnograph) to measure the paco. | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory factors (IL1, IL6, IL13, IL18). Timepoint: before surgery and ?? hours after surgery. Method of measurement: Blood gas analysis.;Lactate level. Timepoint: before, during and after surgery according to following: before induction during induction pre pump, after sternotomy pump?, pump?, pump?, pump off and after closing the ternum. Method of measurement: Blood gas analysis.;Post-operative recovery time. Timepoint: after surgery. Method of measurement: Retention time in recovery room in hours. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Ali Jabbari
Gorgan University of Medical Sciences
Outcome results
None listed