migraine. Migraine
Conditions
Interventions
Intervention 1: Intervention group: The intervention group consumes 1000 mg of spirulina daily in the form of two 500 mg capsules per day after meals for 2 months. Intervention 2: Control group: Contr
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Women with migraine Patients who agree to participate in the study. Diagnosis of migraine by a neurologist based on ICHD-3 criteria Age 18 to 60 years
Exclusion criteria
Exclusion criteria: History of any allergy, intolerance or adverse drug reaction to the study supplement Pregnancy and breastfeeding History of intestinal bypass Following a special diet in the last 3 months Smoking or alcohol consumption Consumption of nutritional and herbal supplements effective on migraines including Riboflavin, evening primrose, feverfew, magnesium and Coenzyme Q10. Having cardiovascular diseases,diabetes, liver, kidney and thyroid diseases and malignancies and other neurological disorders Anticoagulants such as warfarin Patients with immune system disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| High-sensitivity C-reactive protein (hs-CRP). Timepoint: At baseline and after 2 month. Method of measurement: ELISA.;Total antioxidant capacity. Timepoint: At baseline and after 2 month. Method of measurement: colorimetric.;Malondialdehyde. Timepoint: At baseline and after 2 month. Method of measurement: colorimetric.;Serum lactate. Timepoint: At baseline and after 2 month. Method of measurement: colorimetric.;Nitric oxide. Timepoint: At baseline and after 2 month. Method of measurement: colorimetric.;Migraine severity. Timepoint: At baseline and after 2 month. Method of measurement: VAS (Visual Analogue Scale).;Migraine frequency. Timepoint: At baseline and after 2 month. Method of measurement: Number of migraine attacks per month.;Duration of migraine headache. Timepoint: At baseline and after 2 month. Method of measurement: Average duration of migraine attacks in hours per episode.;Migraine Headache Index Score(MHIS). Timepoint: At baseline and after 2 month. Method of measurement: Headache severity × headache frequency × headache duration.;HIT_6(Headache Impact Test). Timepoint: At baseline and after 2 month. Method of measurement: HIT-6 (Headache Impact Test) questionnaire.;Stress. Timepoint: At baseline and after 2 month. Method of measurement: DASS-21 questionnaire.;Anxiety. Timepoint: At baseline and after 2 month. Method of measurement: DASS-21 questionnaire.;Depression. Timepoint: At baseline and after 2 month. Method of measurement: DASS-21 questionnaire.;Quality of Life. Timepoint: At baseline and after 2 month. Method of measurement: MSQ questionnaire(Migraine-Specific Quality of Life Questionnaire). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Gholamreza Askari
Esfahan University of Medical Sciences
Outcome results
None listed