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The effect of lidocaine infusion on pain reduction and the amount of opioid consumption after surgery

The effect of lidocaine infusion during laparotomy surgery on the reduction of postoperative pain and the amount of opioid consumption to control postoperative pain.

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240619062178N1
Enrollment
60
Registered
2024-06-22
Start date
2024-07-22
Completion date
Unknown
Last updated
2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laparotomy surgery.

Interventions

Intervention 1: Intervention group: After induction of anesthesia using midazolam fentanyl as premedication, propofol as hypnotic and etracorium as muscle relaxant, two minutes before intubation until

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 85 Years

Inclusion criteria

Inclusion criteria: Patients undergoing laparotomy surgery with no sensitivity to local anesthetics No chronic use of narcotics and painkillers No use of steroids Age between 18 and 85 years Absence of pregnancy Patients according to American Society of Anesthesiologists (ASA) class one and two Body mass index less than 40 kg/m2 Heart rate above 50 beats per minute The recovery time is less than 45 minutes The interval between the P wave and the R wave in the ECG is no more than 0.2 seconds

Exclusion criteria

Exclusion criteria: Patients who experience a severe drop in blood pressure, severe bradycardia (heart rate less than 40 beats per minute), moderate arterial pressure drop (mean blood pressure less than 60 mm Hg), arrhythmia, or urticaria during surgery following intravenous administration of lidocaine. Patients whose surgery lasts more than 4 hours.

Design outcomes

Primary

MeasureTime frame
Length of hospitalization. Timepoint: After the surgery in the recovery unit and 24 hours after the operation in the ward. Method of measurement: Using a numerical rating scale.;Intensity of pain. Timepoint: After the surgery in the recovery unit and 24 hours after the operation in the ward. Method of measurement: Using a numerical rating scale.;The amount of systemic painkillers used in recovery and the ward. Timepoint: After the surgery in the recovery unit and 24 hours after the operation in the ward. Method of measurement: Using a numerical rating scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Hossein Ardehali

Shahid Beheshti University of Medical Sciences

h-ardehali@sbmu.ac.ir+98 21 2271 8000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026