The effect of eight weeks of aerobic training and green tea supplementation on ABCA1 mRNA‚ APO-A and APO-B expression in PBMC cells in overweight women

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240618062168N1

Enrollment

Registered

2024-09-02

Start date

2024-06-30

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Overweight and obesity. Overweight and obesity

Interventions

Intervention 1: Exercise and herbal medicine group,30 minutes of aerobic exercise and the consumption of green tea supplement with Com Green brand, in the amount of 500 mg, 2 hours before the midday m

Eligibility

Sex/Gender

Female

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Having perfect health Not taking supplements and special drugs

Exclusion criteria

Exclusion criteria: Cardiovascular disease taking weight-affecting medications

Design outcomes

Primary

Measure	Time frame
ATP Binding Cassette Transporter Protein (ABCA1), It is the first member of the ABC transporter family that depends on ATP to transport phospholipids from the membrane. Timepoint: 24 hours before the first training session and 24 hours after the last training session. Method of measurement: RT-PCR.;Apolipoprotein A (Apo_A)? It is an apolipoprotein that is secreted from the liver and forms an important part of HDL. Timepoint: 24 hours before the first training session and 24 hours after the last training session. Method of measurement: ELISA.;Apolipoprotein B (APO_B), It is a protein that plays a role in the structure of lipoproteins and the transportation of fats and cholesterol in the blood. Timepoint: 24 hours before the first training session and 24 hours after the last training session. Method of measurement: ELISA.;MRNA, Messenger RNA (mRNA) is a type of ribonucleic acid RNA that carries genetic information from DNA to ribosomes to produce proteins. Timepoint: 24 hours before the first training session and 24 hours after the last training session. Method of measurement: RNAeasy.	—

Measure

Time frame

ATP Binding Cassette Transporter Protein (ABCA1), It is the first member of the ABC transporter family that depends on ATP to transport phospholipids from the membrane. Timepoint: 24 hours before the first training session and 24 hours after the last training session. Method of measurement: RT-PCR.;Apolipoprotein A (Apo_A)? It is an apolipoprotein that is secreted from the liver and forms an important part of HDL. Timepoint: 24 hours before the first training session and 24 hours after the last training session. Method of measurement: ELISA.;Apolipoprotein B (APO_B), It is a protein that plays a role in the structure of lipoproteins and the transportation of fats and cholesterol in the blood. Timepoint: 24 hours before the first training session and 24 hours after the last training session. Method of measurement: ELISA.;MRNA, Messenger RNA (mRNA) is a type of ribonucleic acid RNA that carries genetic information from DNA to ribosomes to produce proteins. Timepoint: 24 hours before the first training session and 24 hours after the last training session. Method of measurement: RNAeasy.

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Secondary

Measure	Time frame
Total cholesterol (TC), Total cholesterol is a total measure of LDL (low-density lipoprotein) cholesterol, HDL (high-density lipoprotein) cholesterol, and triglycerides in the blood. Timepoint: 24 hours before the first training session and 24 hours after the last training session. Method of measurement: ELISA.;High-density lipoproteins, or HDL, are known as good cholesterol. Timepoint: 24 hours before the first training session and 24 hours after the last training session. Method of measurement: ELISA.;Low-density lipoproteins, known as IDL, are among the bad types of cholesterol. Timepoint: 24 hours before the first training session and 24 hours after the last training session. Method of measurement: ELISA.;Triglyceride is a type of fat that is needed to store energy, make proteins and hormones in the body. Timepoint: 24 hours before the first training session and 24 hours after the last training session. Method of measurement: ELISA.	—

Measure

Time frame

Total cholesterol (TC), Total cholesterol is a total measure of LDL (low-density lipoprotein) cholesterol, HDL (high-density lipoprotein) cholesterol, and triglycerides in the blood. Timepoint: 24 hours before the first training session and 24 hours after the last training session. Method of measurement: ELISA.;High-density lipoproteins, or HDL, are known as good cholesterol. Timepoint: 24 hours before the first training session and 24 hours after the last training session. Method of measurement: ELISA.;Low-density lipoproteins, known as IDL, are among the bad types of cholesterol. Timepoint: 24 hours before the first training session and 24 hours after the last training session. Method of measurement: ELISA.;Triglyceride is a type of fat that is needed to store energy, make proteins and hormones in the body. Timepoint: 24 hours before the first training session and 24 hours after the last training session. Method of measurement: ELISA.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahnaz Beigi

Damghan Islamic Azad University

beigimahnaz821@gmail.com+98 77 3353 5719

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026