Ischemic and non-ischemic heart failure with reduced ejection fraction (less than 40%). Heart failure
Conditions
Interventions
Intervention 1: Intervention group: ischemic and non-ischemic heart failure patients with reduced ejection fraction (less than 40%) who receive colchicine at a dose of 0.5 mg for 3 months in addition
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: chronic heart failure with reduced left ventricular ejection fraction(40%>) The diagnosis of heart failure with reduced ejection fraction has been confirmed at least one year ago At least for 3 months under standard medical treatment Stable and compensated clinical conditions
Exclusion criteria
Exclusion criteria: Acute cardiac ischemic event within a year before or during the study Getting cancer Not taking regular medications in the previous 3 months Acute myocarditis Acute pericarditis Suffering from other chronic inflammatory diseases such as vascular collagen diseases or infectious diseases Heart surgery in the last 6 months Cerebral vascular events during the last 6 months Patients who need colchicine due to other diseases (such as gout) History of colchicine intolerance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hs-CRP plasma level. Timepoint: At the beginning of the study and 12 weeks later. Method of measurement: kit test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Interleukin 6 plasma level. Timepoint: At the beginning of the study and 12 weeks later. Method of measurement: kit test.;Pro-BNP plasma level. Timepoint: At the beginning of the study and 12 weeks later. Method of measurement: Kit test.;NHA functional class. Timepoint: At the beginning of the study and 12 weeks later. Method of measurement: NHA functional class questionnaire.;6MWT. Timepoint: At the beginning of the study and 12 weeks later. Method of measurement: Measuring tape. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAsal Yadollahi
Mashhad University of Medical Sciences
Outcome results
None listed