Investigating the effect of using probiotic supplements in patients with moderate to severe chronic periodontitis

Investigating the effect of using a water-soluble probiotic supplement in the form of mouthwash on periodontal and gingival indicators and common pathogenic bacteria that cause periodontal diseases after scaling and leveling the root surface in patients with moderate to severe chronic periodontitis

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240614062134N1

Enrollment

Registered

2024-08-05

Start date

2024-08-05

Completion date

Unknown

Last updated

2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Moderate to severe chronic periodontitis. Chronic periodontitis

Interventions

Intervention 1: Intervention group:The probiotic capsule with the brand name FamilLact contains 7 useful probiotic species (CFU109).Lactobacillus species: Lactobacillus casei, Lactobacillus acidophilu

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Not smoking, making sure not to be pregnant or breastfeeding, complete general health including not havingSystemic infection and diabetes, autoimmune diseases and immunodeficiency disorders, no history of periodontal treatment in the last 6 months, no use of antibiotics, no use of NSAID drugs and no use of corticosteroids in the last 3 months, moderate to severe chronic generalized periodontitis means having CAL 3 mm and more in more than 30% of the mouth areas, having a periodontal pocket with a depth of 4 mm and more

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Percentage of people with moderate to severe chronic periodontitis. Timepoint: Measurement of indices and bacteria at the beginning of the study (before the start of the intervention) 14 and 28 days after the start of mouthwash use. Method of measurement: Laboratory studies and clinical evaluation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad hasanzadeh

Birjand University of Medical Sciences

Mohammad1379hnz@gmail.com+98 56 3239 5000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026