Skip to content

Evaluation of the effect of Misswake herbal mouthwash in children with cystic fibrosis

The effect of Misswake herbal mouthwash (containing clove and lavender extracts) on periodontal indices and salivary interleukin 1 beta biomarkers in children with cystic fibrosis: A Randomized Clinical Trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240611062085N1
Enrollment
44
Registered
2024-06-26
Start date
2024-06-09
Completion date
Unknown
Last updated
2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cystic fibrosis. Cystic fibrosis

Interventions

Intervention 1: Intervention group: Measurement of periodontal indices, prophylaxis, fluoride therapy and oral hygiene education (toothbrush and toothpaste), mouthwash. Intervention 2: Control group:

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
6 Years to 12 Years

Inclusion criteria

Inclusion criteria: A child with a definitive diagnosis of cystic fibrosis who is in the period of mixed dentition (patients 6 to 12 years old). Patients with moderate severity of cystic fibrosis according to the opinion of the attending physician (based on spirometry), without mental problems and metabolic and endocrine diseases, do not take analgesics at the moment, do not have xerostomia and in the next 6 months from products be Oral and dental antimicrobials have not been used.

Exclusion criteria

Exclusion criteria: Children who, during the 4-week follow-up period during the study, have made a change in their medication regimen in terms of taking antibiotics, have taken analgesics, currently have a bacterial or viral infectious disease, and based on the reports of their parents and If the reminder tables do not have the necessary cooperation, they will be excluded from the study.

Design outcomes

Primary

MeasureTime frame
Salivary Intrlukin 1-beta. Timepoint: 1 month. Method of measurement: Saliva sampling.;Plaque index. Timepoint: 1 month. Method of measurement: Periodontal indexe.;Gingival index. Timepoint: 1 month. Method of measurement: loe & Sillness method.;Simplified Oral Hygiene index. Timepoint: 1 month. Method of measurement: Periodontal index.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Valizadeh

Mashhad University of Medical Sciences

Valizadehm@mums.ac.ir00985138049

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026