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Investigating the effect of massage or bath with chicory extract on jaundice of term newborn

Comparison of the effect of massage and bath with chicory extract on bilirubin levels in term newborns and under phototherapy: a randomized controlled clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240609062054N1
Enrollment
105
Registered
2024-12-04
Start date
2024-12-21
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neonatal physiological jaundice. Unspecified jaundice

Interventions

Intervention 1: Intervention group: massage In the massage group, massage will be performed accordi

Sponsors

Mazandaran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
1 Days to 28 Days

Inclusion criteria

Inclusion criteria: 1. Absence of anomalies Absence of congenital infections Newborns with a gestational age of 37-42 weeks Newborns weighing 2500-4000 grams Apgar score between 7 and 10 in the first minute after birth Apgar score between 7 and 10 in the fifth minute after birth Indirect hyperbilirubinemia in 24 hours or more after birth Bilirubin level 12-20 mg/dL Breastfeeding Jaundice in the first week after birth Non-hemolytic jaundice Absence of contraindications to massage Absence of restrictions on bathing Absence of restrictions on massaging the baby Absence of any medication by the mother Absence of gastrointestinal disease Absence of infections

Exclusion criteria

Exclusion criteria: 1. G6PD deficiency Positive direct Coombs test Jaundice requiring blood exchange Treatment with intravenous fluids, antibiotics, or oxygen therapy Giving medications such as milk thistle drops or clofibrate capsules to reduce bilirubin Hypothermia with an axillary temperature of less than 36.5 degrees Celsius Smoking, alcohol, or drug use by the mother during pregnancy and after delivery History of skin allergies in family members Any allergy to chicory extract in the infant Increase in bilirubin levels during treatment to more than 20 mg/dL Dubin-Johnson and Gilbert syndrome Parental unwillingness to continue treatment Discharge or death of the infant

Design outcomes

Primary

MeasureTime frame
Bilirubin. Timepoint: Before the intervention and end of the intervention. Method of measurement: blood sample.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactOmmolbanin Zare

Mazandaran University of Medical Sciences

mahyazare@yahoo.com+98 11 3304 4030

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026