Effect of insulin glucose solution in orthotopic liver transplantation

Investigating the effect of administration of insulin glucose solution in the preanhepatic phase on the heart outcome of patients undergoing orthotopic liver transplantation

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240606062025N1

Enrollment

Registered

2024-06-15

Start date

2024-06-19

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver transplantation. Liver transplant status

Interventions

Intervention 1: Intervention group: Patients receiving 500 cc of dextrose 5% along with 10 units of insulin during the first hour after induction. Intervention 2: Control group: Patients receiving 500

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: diabetes Potassium level less than 3

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Cardiac output. Timepoint: Before the start of the intervention, immediately after the end of the intervention, one week after the intervention. Method of measurement: LidCo.;Systemic vascular resistance. Timepoint: Before the start of the intervention, immediately after the end of the intervention, one week after the intervention. Method of measurement: LidCo.;Cardiac hemodynamic. Timepoint: Before the start of the intervention, immediately after the end of the intervention, one week after the intervention. Method of measurement: LidCo.	—

Measure

Time frame

Cardiac output. Timepoint: Before the start of the intervention, immediately after the end of the intervention, one week after the intervention. Method of measurement: LidCo.;Systemic vascular resistance. Timepoint: Before the start of the intervention, immediately after the end of the intervention, one week after the intervention. Method of measurement: LidCo.;Cardiac hemodynamic. Timepoint: Before the start of the intervention, immediately after the end of the intervention, one week after the intervention. Method of measurement: LidCo.

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Secondary

Measure	Time frame
Lactate. Timepoint: Before the intervention, immediately after the intervention, one week after the intervention. Method of measurement: Laboratory blood test.;Creatinine. Timepoint: Before the intervention, immediately after the intervention, one week after the intervention. Method of measurement: Laboratory blood test.;Liver function tests (LFT). Timepoint: Before the intervention, immediately after the intervention, one week after the intervention. Method of measurement: Laboratory blood test.;Brain natriuretic peptide (BNP). Timepoint: Before the intervention, immediately after the intervention, one week after the intervention. Method of measurement: Laboratory blood test.;Tracheal extubation. Timepoint: after intervention. Method of measurement: The number of days the patient is intubated.;Length of stay in ICU. Timepoint: after intervention. Method of measurement: The number of days the patient stays in the intensive care unit.;Length of stay in hospital. Timepoint: after intervention. Method of measurement: The number of days the patient stays in the hospital.	—

Measure

Time frame

Lactate. Timepoint: Before the intervention, immediately after the intervention, one week after the intervention. Method of measurement: Laboratory blood test.;Creatinine. Timepoint: Before the intervention, immediately after the intervention, one week after the intervention. Method of measurement: Laboratory blood test.;Liver function tests (LFT). Timepoint: Before the intervention, immediately after the intervention, one week after the intervention. Method of measurement: Laboratory blood test.;Brain natriuretic peptide (BNP). Timepoint: Before the intervention, immediately after the intervention, one week after the intervention. Method of measurement: Laboratory blood test.;Tracheal extubation. Timepoint: after intervention. Method of measurement: The number of days the patient is intubated.;Length of stay in ICU. Timepoint: after intervention. Method of measurement: The number of days the patient stays in the intensive care unit.;Length of stay in hospital. Timepoint: after intervention. Method of measurement: The number of days the patient stays in the hospital.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Gharehbeglou

Shahid Beheshti University of Medical Sciences

m.gharebeglou@zaums.ac.ir+98 21 2303 1505

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026