non-alcoholic fatty liver disease (NAFLD). Fatty (change of) liver, not elsewhere classified
Conditions
Interventions
Intervention 1: intervention group: Patients in the groups receiving resveratrol supplement received 1 capsule of 400 mg daily, one hour after meals for 8 weeks. In order to assign the supplement, fir
Sponsors
Islamic Azad University
Eligibility
Sex/Gender
Male
Age
45 Years to 60 Years
Inclusion criteria
Inclusion criteria: Willingness to participate in the research Men aged 45-60 years Suffering from non-alcoholic fatty liver grade 1-3 based on laboratory and ultrasound methods
Exclusion criteria
Exclusion criteria: Unwillingness to participate in the study Use of any nutritional supplement (omega-3 supplement) or supplements that have anti-inflammatory and antioxidant properties in the last 3 months or during the study. Suffering from kidney failure, cardiovascular diseases, breast cancer and thyroid diseases. Smoking and alcohol consumption Patients using NSAIDs, corticosteroids (prednisone, prednisolone and hydrocortisone), thiazide diuretics (furosemide and hydrochlorothiazide) and second generation antipsychotics (olanzapine and clozapine). have taken these drugs and during the study people were advised to refrain from taking these drugs.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determining the effect of resveratrol supplementation along with intermittent exercises on ALT enzyme changes in patients with non-alcoholic fatty liver disease (NAFLD) in intervention and control groups. Timepoint: Eight Weeks. Method of measurement: Before and after the intervention, venous blood samples were taken from all participants after 12-14 hours of fasting, and after serum separation by centrifugation, serum ALT was measured by ELISA method.;Determining the effect of taking resveratrol supplement along with intermittent exercises on AST enzyme changes in patients with non-alcoholic fatty liver disease (NAFLD) in intervention and control groups. Timepoint: Eight Weeks. Method of measurement: Before and after the intervention, venous blood samples were taken from all participants after 12-14 hours of fasting, and after serum separation by centrifugation, serum AST was measured by ELISA method.;Determining the effect of taking resveratrol supplement along with intermittent exercises on changes in total antioxidant capacity (TAC) in patients with non-alcoholic fatty liver disease (NAFLD) in intervention and control groups. Timepoint: Eight Weeks. Method of measurement: Plasma TAC was measured by spectrophotometric method and using RANDOX kit, by autoanalyzer (Abbot Model Aclyon 300).;Determining the effect of taking resveratrol supplement along with periodic exercises on malondialdehyde (MDA) changes in patients with non-alcoholic fatty liver disease (NAFLD) in intervention and control groups. Timepoint: Eight Weeks. Method of measurement: The basis of the serum MDA measurement method is based on the reaction with thiobarbituric acid (TBA), extraction with normal butanol, measuring the absorbance of Barosh spectrophotometry and comparing the absorbance with the standard curve.;Determining the effect of resveratrol supplementation along with intermittent exercises on the changes of interleukin-6 (IL-6) in patients with non-alcoholic fatty liver disease (NAFLD) | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZaher Etemad
Islamic Azad University
Outcome results
None listed