Mild to moderate Traumatic Brain Injury. Intracranial injury
Conditions
Interventions
Intervention 1: Intervention group: One tablet of 8 mg buprenorphine orally, single dose, is administered to patients in the intervention group once after hospital admission. Intervention 2: Control g
Sponsors
Bagheiat-allah University of Medical Sciences
Boushehr University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients aged 18 to 65 with mild to moderate brain injury severity, as determined by a Glasgow Coma Scale (GCS) score of 9 and above
Exclusion criteria
Exclusion criteria: Patients with penetrating head trauma, time from injury to hospital admission more than 4 hours, associated spinal cord injury, candidate for craniotomy, concomitant with other traumas and opioid substance abuse. Associated with cardiovascular diseases along with hemodynamic instability. History or incidence of various cancers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Score of the Visual Analogue Scale (VAS). Timepoint: Day 1 and 14 after taking medication. Method of measurement: Visual analogue scale (VAS).;Score of Glasgow Outcome Scale Extended (GOSE). Timepoint: Day 1 and 14 after taking medication. Method of measurement: Glasgow Outcome Scale Extended (GOSE) Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Score of The Working Memory Questionnaire. Timepoint: Day 1 and 14 after taking medication. Method of measurement: The Working Memory Questionnaire.;Side effects related to the drug. Timepoint: Day 1 and 14 after taking medication. Method of measurement: If the patient confirms any side effects of the drug "Yes" otherwise "No". | — |
Countries
Iran (Islamic Republic of)
Contacts
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Bagheiat-allah University of Medical Sciences
Outcome results
None listed