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Investigating the effect of bromelain in preventing mucositis caused by 5 fluorouracil (5-FU( in patients with gastrointestinal cancer

Investigating the effect of bromelain in preventing mucositis caused by 5 fluorouracil (5-FU( in patients with gastrointestinal cancer

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240601061970N1
Enrollment
30
Registered
2024-06-21
Start date
2024-06-21
Completion date
Unknown
Last updated
2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patients with gastrointestinal cancer. Malignant neoplasm of ill-defined sites within the digestive system

Interventions

Intervention 1: Control group: The first and second session of each patient . In this study, patients with digestive system cancer will be included in the study and in their treatment period with 5-FU

Sponsors

Semnan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients with cancer of the digestive system who take fu5-bolus (within half an hour)take

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Effect of bromelain in preventing mucositis caused by five fluorouracil (5-FU) in patients with gastrointestinal cancer. Timepoint: In this study, patients with digestive system cancer will be included in the study and in their treatment period with 5-FU, they will be in the control group in the first and second injection rounds and in the third and fourth rounds in the case group (use of bromelain tablets). took Each patient will be examined 48 hours to one week after using this pill, and their degree of mucositis will be checked and recorded. Due to the fact that in colorectal cancers, 12 sessions of 5 fu chemotherapy drugs are injected, the first four sessions are without bromelain administration and the second four sessions are with bromelain, and then the side effects of oral mucositis are compared. Method of measurement: Oral mucositis will be graded based on the World Health Organization index, and the severity of mucositis will be recorded in a special form for each patient.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Farahnaz Ghahremanfard

Semnan University of Medical Sciences

anahid.n78@gmail.com+98 912 731 1887

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026