Obsessive-compulsive disorder. Obsessive-compulsive disorder
Conditions
Interventions
Intervention 1: Intervention group: 27 patients will receive empagliflozin 25 mg once daily in combination with fluvoxamine, starting at 100 mg once daily for one month, then increased to 200 mg dail
Sponsors
Karaj University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: People aged 18 to 60 who has DSM-5 diagnostic criteria for moderate to severe OCD. Consent of patients to participate in the study They have the Yale-Brown Algebraic Obsession Scale (Y-BOCS) above 21.
Exclusion criteria
Exclusion criteria: Being psychotic Have other disorders diagnosed in psychiatric axis I. Used any type of psychoactive drug in the last 6 weeks Have taken OCD medication in the last 6 weeks and ECT in the last two months Participation in psychotherapy sessions in the last 6 weeks Hypothyroidism History of cardiovascular disease Pregnancy or breastfeeding kidney disease Type 1 diabetes Age less than 18 and more than 60 IQ less than 70 History of seizures and brain disorders Taking beta-blocker drugs, amlodipine, insulin, glipizide, metformin, linagliptin, sitagliptin, liraglutide, lasix, lithium, linezolid Abuse of drugs and medicine except nicotine and caffeine Any type of kidney, urinary tract and genital infection The presence of MAO inhibitors such as Azilact, Marplan ?Aspirin, Gabapentin, Pantoprazole, and Omeprazole in the patient's medication list Pancreatitis Hypotension
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| OCD score according to the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Timepoint: 1st visit (before the intervention) and 4, 10, and 12 weeks after drug/placebo administration. Method of measurement: Yale-Brown Obsessive Compulsive Scale (Y-BOCS). | — |
Secondary
| Measure | Time frame |
|---|---|
| Y-BOCS score. Timepoint: 1st day 4th week ,10th week and 12 week after administration of Empagliflozin /Placebo. Method of measurement: Yale-Brown Obsessive Compulsive Scale (Y-BOCS). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactReyhaneh Hadi
Karaj University of Medical Sciences
Outcome results
None listed