Obstructive sleep apnea. Obstructive sleep apnea (adult) (pediatric)
Conditions
Interventions
Intervention 1: Intervention group 1: Patients suffering from obstructive sleep apnea receive two puffs in each nostril of a spray containing Indian chestnut seed extract equivalent to 1.25 mg/L of ae
Sponsors
Birjand University of Medical Sciences
Eligibility
Sex/Gender
All
Age
11 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with a history of sleep disorder and nocturnal snoring and frequent night awakenings and daily fatigue or uncontrolled blood pressure that is mentioned in the history of sleep apnea The number of apneas greater than five obstructive apneas per hour Stop-Bang test score of 4 or more Have a score of 6 or more on the Petersburg Sleep Questionnaire
Exclusion criteria
Exclusion criteria: Acute renal and liver disease Pregnancy Breastfeeding Age under 10 years Receiving anticoagulant drugs Having cardiac pace maker Hypersensitivity to any drugs Substance abuse Dementia History of liver and kidney diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in Beck Depression Inventory (BDI). Timepoint: before, 1 and 2 months after the intervention. Method of measurement: Beck Depression Inventory questionnaire.;Changes in Hamilton Anxiety Inventory (HRSA). Timepoint: before, 1 and 2 months after the intervention. Method of measurement: Hamilton Anxiety Inventory questionnaire.;Changes in Pittsburgh Sleep Quality Questionnaire (PSQI). Timepoint: before, 1 and 2 months after the intervention. Method of measurement: Pittsburgh Sleep Quality Questionnaire.;Quality of Life Questionnaire. Timepoint: before, 1 and 2 months after the intervention. Method of measurement: Quality of Life Questionnaire.;Insomnia and Daily Fatigue Severity Questionnaire. Timepoint: before, 1 and 2 months after the intervention. Method of measurement: Insomnia and Daily Fatigue Severity Questionnaire.;Brain Map, and EEG. Timepoint: before, 1 and 2 months after the intervention. Method of measurement: performing EEG and brain map.;Changes in Stop-Bang sleep apnea questionare. Timepoint: before, 1 and 2 months after the intervention. Method of measurement: Stop-Bang sleep apnea questionare.;Determining the number of apnea and hypopnea and changes in heart rate and oxygen saturation. Timepoint: before, 1 and 2 months after the intervention. Method of measurement: Polysomnography.;Changes in serum levels of CBC? ALT? AST? TSH? Bu? Cr? ESR ? CRP ?NF-?B? IL-6 IL 1 , TNF. Timepoint: before, 1 and 2 months after the intervention. Method of measurement: assay of serum level. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyed Mohammad Mousavi Mirzaei
Birjand University of Medical Sciences
Outcome results
None listed