Radiotherapy-induced mucositis in head and neck patients. Oral mucositis (ulcerative) due to radiation
Conditions
Interventions
Intervention 1: - Intervention group: Dexamethasone mouthwash (0.5 mg of dexamethasone in 10 ml of normal saline) - 10 cc of the solution is gargled in the mouth four times a day from the day before r
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Performance level of KPS=70 (or ECOG score=0-1) Newly diagnosed patient Having a pathological diagnosis of head and neck cancer Presence of adjuvant or definitive radiotherapy indication The treatment dose is at least 60 Gry Placement of at least half of the oral cavity in the radiotherapy treatment field
Exclusion criteria
Exclusion criteria: Lack of consent to participate in the study Presence of chronic kidney (eGFR three times normal) History of previous malignancy History of previous radiation therapy in the head and neck area History of hypersensitivity reaction to dexamethasone mouthwash
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment complications based on the checklist designed based on CTCAE v4.0 and the World Health Organization system. Timepoint: Weekly from the beginning of treatment until two months after treatment. Method of measurement: The basis of the checklist designed based on CTCAE v4.0 and the World Health Organization system. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNooshin Dindar
Shiraz University of Medical Sciences
Outcome results
None listed