ulcerative colitis. K51
Conditions
Interventions
Intervention 1: Intervention group: 600 mg of alpha lipoic acid (in the form of two 300 mg capsules made by Raha company) for 8 weeks. Intervention 2: Control group: tow placebo per day (made by Raha
Sponsors
Ahvaz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
25 Years to 55 Years
Inclusion criteria
Inclusion criteria: Age 25 to 55 years Body mass index in the range of 18.5-27 Diagnosing ulcerative colitis according to clinical, colonoscopic, and histopathological findings by a gastroenterologist Lack of cancer, other autoimmune and inflammatory diseases Having a mild to moderate form of the disease (the severity of the disease in people is determined by a gastroenterologist based on international standards) Not taking antioxidant supplements in the last 2 months Willingness to participate in the intervention Lack of pregnancy, breastfeeding, or taking oral contraceptives in women
Exclusion criteria
Exclusion criteria: Recurrence of the disease that leads to hospitalization Unwillingness to continue participating in the intervention Changing the drug dose during the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Interleukin 1 beta. Timepoint: The beginning of the study-The end of the eighth week. Method of measurement: ELISA kit.;Interleukin 8. Timepoint: The beginning of the study-The end of the eighth week. Method of measurement: ELISA kit.;Malondialdehyde. Timepoint: The beginning of the study-The end of the eighth week. Method of measurement: colorimetric method.;Superoxide dismutase. Timepoint: The beginning of the study-The end of the eighth week. Method of measurement: colorimetric method.;Clinical symptoms. Timepoint: The beginning of the study-The end of the eighth week. Method of measurement: partial mayo score questionnaire.;Quality of life. Timepoint: The beginning of the study-The end of the eighth week. Method of measurement: Inflammatory Bowel Disease Questionnaire.;Physical activity. Timepoint: The beginning of the study-The end of the eighth week. Method of measurement: IPAQ Physical Activity Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAva kheirizadeh
Ahvaz University of Medical Sciences
Outcome results
None listed