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endometrial preparation with estradiol and letrozol in IVF cycles

Comparison of endometrial preparation with estradiol and letrozol in IVF cycles returned from freezing

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240521061861N1
Enrollment
178
Registered
2024-07-08
Start date
2024-04-28
Completion date
Unknown
Last updated
2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Female infertility

Interventions

Intervention 1: Intervention group: including 89 women aged 18 to 42 who meet the conditions to enter the study. In order to prepare the endometrium, on day 3-7 of menstruation, 5 mg of letrozole is g

Sponsors

Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 42 Years

Inclusion criteria

Inclusion criteria: Women aged 18 to 42 with frozen embryos

Exclusion criteria

Exclusion criteria: Mother's underlying disease such as thrombophilia, uncontrolled diabetes, uncontrolled hyperprolactinemia, uncontrolled thyroid disorder. Lack of informed consent to participate in the study Hydrosalpinx Having uterine anomaly and premature ovarian insufficiency (POF) and low quality embryos Repeated implantation failure

Design outcomes

Primary

MeasureTime frame
Investigating the effect of oral letrozole administration on endometrial thickness. Timepoint: From the third to the fifth day of menstruation until the tenth day. Method of measurement: Transvaginal ultrasound.;Investigating the effect of oral estradiol administration on endometrial thickness. Timepoint: From the second day to the tenth day of menstruation. Method of measurement: Transvaginal ultrasound.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSomayeh Ebadisoflou

Iran University of Medical Sciences

ebadisoflo.s@iums.ac.ir+98 21 8670 2030

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026