Schizophrenia spectrum disorder. Schizophrenia
Conditions
Interventions
Intervention 1: Intervention Group 1: Computer-based Cognitive Rehabilitation. Participants in this group will perform cognitive rehabilitation exercises using the Captain Log software to improve cogn
Sponsors
The University of Mohaghegh Ardabili
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: Age between 20 and 60 years basic literacy in reading and writing definite diagnosis of schizophrenia spectrum disorder based on DSM-5 criteria and confirmed by a psychiatrist at least one year since disease onset and hospitalization stable medication regimen and clinical stability during the past three months (no medication change and stable psychotic symptoms) no history of major neurological or cognitive disorders, epilepsy, brain injury, or intellectual disability ability to participate and cooperate in cognitive rehabilitation sessions and cognitive assessments providing informed consent by the patient or legal guardian and obtaining institutional approval for participation
Exclusion criteria
Exclusion criteria: Presence of major neurological or cognitive disorders such as epilepsy, brain injury, or intellectual disability Current or recent (within the past six months) substance abuse or alcohol dependence Clinical instability or recent changes in antipsychotic medication during the past three months Presence of severe or disabling physical illness that prevents participation in therapeutic sessions or study assessments Inability to read, write, or understand test instructions and cognitive rehabilitation tasks Dominant psychiatric comorbidities other than schizophrenia spectrum disorders that may interfere with diagnosis Lack of informed consent or refusal to participate by the patient or legal guardian Pregnancy or breastfeeding (if female participants are included)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The cognitive performance scores of patients with chronic schizophrenia, assessed using standard neuropsychological tests (including the N-Back, Simple Stroop, and Continuous Performance Test). Timepoint: Outcome measures will be assessed at three time points: pre-test (before the intervention), post-test (immediately after the intervention), and two-month follow-up (two months after the intervention). Method of measurement: Cognitive functions of participants will be assessed using standardized neuropsychological tests and their computerized versions. Response inhibition, selective attention, and cognitive flexibility will be measured by the Simple Stroop Test; working memory and processing speed by the N-Back Task; sustained attention and impulsivity control by the Continuous Performance Test; and social cognition by the Reading the Mind in the Eyes Test. All assessments will be administered by a trained evaluator in a controlled environment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive Flexibility: Changes in cognitive flexibility after the intervention will be assessed. Timepoint: In this study, the secondary outcome variables will be measured at three time points: before the intervention (pre-test), immediately after the completion of the intervention (post-test), and two months after the intervention (follow-up). Method of measurement: Simple Stroop Test.;Selective Attention: The effect of the intervention on selective attention will be evaluated. Timepoint: In this study, the secondary outcome variables will be measured at three time points: before the intervention (pre-test), immediately after the completion of the intervention (post-test), and two months after the intervention (follow-up). Method of measurement: Simple Stroop Test.;Response Inhibition: The study examines changes in response inhibition following the intervention. Timepoint: In this study, the secondary outcome variables will be measured at three time points: before the intervention (pre-test), immediately after the completion of the intervention (post-test), and two months after the intervention (follow-up). Method of measurement: Simple Stroop Test.;Processing Speed: Processing speed will be measured as a secondary outcome. Timepoint: In this study, the secondary outcome variables will be measured at three time points: before the intervention (pre-test), immediately after the completion of the intervention (post-test), and two months after the intervention (follow-up). Method of measurement: Simple Stroop Test.;Sustained Attention: Improvements in sustained attention after the intervention will be assessed. Timepoint: In this study, the secondary outcome variables will be measured at three time points: before the intervention (pre-test), immediately after the completion of the intervention (post-test), and two months after the intervention (follow-up). Method of measurement: Continuous Performance Test.;Impulsivity Control: The effect of the intervention on impulsi | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahdis Alaei Kalajahi
The University of Mohaghegh Ardabili
Outcome results
None listed