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Effect of Oral and Vaginal Misoprostol

Evaluation and Comparison of the Effect of Vaginal and Oral Misoprostol for Cervical Ripening in Post-term Primigravida Mothers

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240519061844N1
Enrollment
80
Registered
2025-06-14
Start date
2025-06-22
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-term. Post-term pregnancy

Interventions

Intervention 1: first Intervention group: Substance Name: Misoprostol Chemical Composition and Concentration: Misoprostol, Prostaglandin E1 analog Dosage: 50 micrograms Frequency of Administration: Ev

Sponsors

Bandare-abbas University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Post-term primigravida mothers who have voluntarily agreed to participate in the study and have referred to Shariati Hospital in Bandar Abbas

Exclusion criteria

Exclusion criteria: Presence of spontaneous uterine contractions Previous uterine surgery Oligohydramnios Placenta previa Intrauterine Growth Restriction (IUGR) Cesarean section Umbilical cord prolapse Unexplained vaginal bleeding Contraindications to the administration of prostaglandins Contraindications to labor induction Presence of renal or hepatic disease Uncontrolled epilepsy Allergy Intolerance

Design outcomes

Primary

MeasureTime frame
Bishop Score. Timepoint: Baseline (before intervention): The Bishop score is measured at the baseline before the administration of the first dose of misoprostol.4 hours after each dose: The Bishop score is measured 4 hours after the administration of each dose of misoprostol to monitor initial changes in cervical ripening.8 hours after each dose: The Bishop score is measured 8 hours after the administration of each dose of misoprostol to track changes in cervical ripening.Finally, after achieving a Bishop score of 7 or after 6 doses: The Bishop score is measured either after achieving a score of 7 or after the administration of up to 6 doses of misoprostol, whichever occurs first. Method of measurement: Cervical dilation: Measured in centimeters using clinical examination by a specialist physician.Cervical effacement: Percentage of cervical thinning determined by clinical examination by a specialist physician.Cervical position: Position of the cervix (posterior, mid, anterior) assessed by clinical examination by a specialist physician.Cervical consistency: Softness, medium, or firmness of the cervix determined by clinical examination by a specialist physician.Fetal station: Position of the fetal head relative to the cervix assessed by clinical examination by a specialist physician.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNastaran Taherpour

Bandare-abbas University of Medical Sciences

Nst94@yahoo.com+98 76 3222 9507

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026