Drug resistant epilepsy. Epilepsy and recurrent seizures
Conditions
Interventions
Intervention group: ketogenic diet with appropriate calories by 4:1 or 3:1 ratio.
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
2 Years to 15 Years
Inclusion criteria
Inclusion criteria: Age more than 2 years and less than 15 years The patient's seizures have not been controlled using two first-line anticonvulsants for at least six months, and the patient has an average of one seizure per month. Parents or caregivers should have proper training to start, continue the diet, measure urine ketones, and record information in the relevant form. Informed consent of the patient's parents for the child's participation in the study
Exclusion criteria
Exclusion criteria: The child with liver diseases, progressive neurological disease, metabolic disorders with ammonia levels higher than normal, or other systemic diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver enzymes level including aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Timepoint: Baseline and 3 months after intervention. Method of measurement: Colorimetric method. | — |
Secondary
| Measure | Time frame |
|---|---|
| Triglyceride level. Timepoint: Baseline and 3 months after intervention. Method of measurement: colorimetric method. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactKhatereh Rezazadeh
Tabriz University of Medical Sciences
Outcome results
None listed