The effect of cooled anesthetic compared to increasing its volume on the success of inferior alveolar block anesthesia by articaine

Investigating the effect of cooled anesthetic compared to increasing its volume on the success of inferior alveolar block anesthesia by articaine in mandibular first molars with symptomatic irreversible pulpitis: a randomized controlled clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240518061836N1

Enrollment

135

Registered

2024-05-23

Start date

2024-06-19

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

symptomatic irreversible pulpitis. Pulpitis

Interventions

Intervention 1: Intervention group: In the first group, anesthesia injection will be performed by inferior alveolar block method by articaine 4% with 1200,000 epinephrine kept at room temperature. A 2

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients without systemic diseases Patients aged 18-65 years No facial paresthesia Do not take analgesic drugs 6 hours before the treatment Not taking drugs that interfere with anesthesia (tricyclic antidepressant-propranolol) Absence of lesions and pathology in the anesthesia injection area Absence of periodontal problems in the first molar area of ??the mandible Patients with mandibular first molars with symptomatic irreversible pulpitis

Exclusion criteria

Exclusion criteria: Patients with congenital anomalies and structural defects in the first molar of the mandible Patients undergoing radiotherapy or chemotherapy Patients with an allergy to anesthetics Patients taking painkiller, anti-inflammatory or sedative drugs in the last 12 hours Smoker patients Mandibular first molar tooth necrosis or irreversible pulpitis

Design outcomes

Primary

Measure	Time frame
Anesthesia. Timepoint: 20 minutes after pulp anesthesia. Method of measurement: 20 minutes after the injection, anesthesia is evaluated by electrical pulp test.	—

Secondary

Measure	Time frame
Pain. Timepoint: before injection and 20 minutes after injection. Method of measurement: Before anesthesia injection, the patients will be explained to rate their pain during the root canal treatment process using a visual analogue scale (VAS), with 0 cm indicating the absence of pain and 17 cm indicating the worst. 20 minutes after the injection, this assessment will be repeated and compared.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBafrin Fattahi

Tabriz University of Medical Sciences

baf.fattahide@gmail.com+98 939 168 2663

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026