Investigating the effectiveness of intranasal PRF treatment compared to standard treatment on mucosal healing at the cautery site during rhinosinusitis endoscopic surgery in chronic rhinosinusitis patients

Investigating the effectiveness of intranasal PRF treatment compared to standard treatment on mucosal healing at the cautery site during rhinosinusitis endoscopic surgery in chronic rhinosinusitis patients referred to Taleghani Hospital during 1403-1405

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240518061832N1

Enrollment

Registered

2024-10-17

Start date

2024-10-06

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic sinusitis after endoscopic surgery.

Interventions

Intervention 1: Intervention group: In this study, all adult patients over 18 years of age suffering from chronic rhinosinusitis undergoing FESS surgery who referred to Taleghani Hospital from 1403 to

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Bilateral chronic rhinosinusitis with nasal polyps A difference in scores of two or less LUND MACKY SCORE between both nasal cavities Age between 18 and 60 years

Exclusion criteria

Exclusion criteria: Patients with unilateral nasal polyps antrochoanal polyp Chronic rhinosinusitis without polyps History of nose or sinus surgery Immunity deficiency

Design outcomes

Primary

Measure	Time frame
Determining and comparing the effectiveness of intranasal platelet-rich fibrin (PRF) treatment with standard treatment on wound healing at the cautery site during FESS surgery in chronic sinusitis patients. Timepoint: Patients 3 days after surgery and after removing tampons if any and two weeks after surgery and one month after surgery and three months after surgery in terms of shortness of breath and bleeding and endoscopic findings in terms of adhesion and wound healing and site Wounds and cautery are checked. Method of measurement: Accordingly, the following were scored by endoscopic assessment: Adhesion (0 = none, 1 = adhesion not affecting sinus drainage, 2 = moderate adhesion affecting sinus drainage, 3 = complete adhesion between the middle and lateral prongs of the nasal wall (bleeding) 0 = none; 1 = minimal, confined to nasal cavity; 3 = severe, need for cauterization (0 = minimal, 2 = moderate, 3 = severe) (0) = no infection, 1 = mild purulent mucous discharge, 2 = moderate purulent mucous discharge, 3 = severe purulent mucous discharge) granulation (0 = none, 1 = minimal, 2 = moderate, 3 = severe) also from patient questionnaire NOSE and history are taken before and after surgery and during the follow-up period. Finally, all the information is collected and then the statistical analysis of the data is done.	—

Measure

Time frame

Determining and comparing the effectiveness of intranasal platelet-rich fibrin (PRF) treatment with standard treatment on wound healing at the cautery site during FESS surgery in chronic sinusitis patients. Timepoint: Patients 3 days after surgery and after removing tampons if any and two weeks after surgery and one month after surgery and three months after surgery in terms of shortness of breath and bleeding and endoscopic findings in terms of adhesion and wound healing and site Wounds and cautery are checked. Method of measurement: Accordingly, the following were scored by endoscopic assessment: Adhesion (0 = none, 1 = adhesion not affecting sinus drainage, 2 = moderate adhesion affecting sinus drainage, 3 = complete adhesion between the middle and lateral prongs of the nasal wall (bleeding) 0 = none; 1 = minimal, confined to nasal cavity; 3 = severe, need for cauterization (0 = minimal, 2 = moderate, 3 = severe) (0) = no infection, 1 = mild purulent mucous discharge, 2 = moderate purulent mucous discharge, 3 = severe purulent mucous discharge) granulation (0 = none, 1 = minimal, 2 = moderate, 3 = severe) also from patient questionnaire NOSE and history are taken before and after surgery and during the follow-up period. Finally, all the information is collected and then the statistical analysis of the data is done.

—

Countries

Iran (Islamic Republic of)

Contacts

Public Contactvahid ghasem amooeian

Shahid Beheshti University of Medical Sciences

vahidvm2m@gmail.com+98 21 2243 9770

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026