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Investigating the effect of tizanidine pre-operative administration on pain after surgery of mandibular fractures: a three-blind clinical trial

Investigating the effect of tizanidine pre-operative administration on pain after surgery of mandibular fractures: a three-blind clinical trial. Triple Blinded Randomized Clinical Trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240517061819N2
Enrollment
120
Registered
2024-09-21
Start date
2024-09-22
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain in jaw. Disease of jaws, unspecified

Interventions

Sponsors

Kerman University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients between the ages of 18 and 40 Patients who are categorized in the 1st and 2nd group according to the ASA (American Society of Anesthesiology ) Patients with isolated mandibular fracture Complete the informed consent

Exclusion criteria

Exclusion criteria: Patients with a history of drug allergy, Motion Sickness, addiction or psychological problems and hypotension and bradycardia Patients with upper gastrointestinal problems such as gastric ulcer, reflux, pyloric stenosis

Design outcomes

Primary

MeasureTime frame
Pain degree. Timepoint: 1 hour, 3 hours, 6 hours, 12 hours, and 24 hours postoperatively. Method of measurement: Visual analogue scale (VAS) for pain.

Secondary

MeasureTime frame
Presence or absence of nausea and vomiting. Timepoint: Immediately after recovery and 1 hour, 3 hours, 6 hours, 12 hours, and 24 hours postoperatively. Method of measurement: scoring (0=non, 1=nausea and vomiting).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Labafchi

Kerman University of Medical Sciences

a.labafchi@kmu.ac.ir+98 51 3551 1852

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026