Condition 1: Premature Rupture of Amniotic Membranes. Condition 2: Chorioamnionitis. Preterm premature rupture of membranes, unspecified as to length of time between rupture and onset of labor Chorioamnionitis, second trimester
Conditions
Interventions
Intervention 1: Intervention group: They will be given 1000 mg of oral azithromycin (Two 500 mg tablets) as a single dose and 2 gr of intravenous ampicillin every 6 hours for 48 hours, followed by 500
Sponsors
Zanjan University of Medical Sciences
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Gestational age between 26 and 34 weeks Singleton pregnancy Confirmed Premature rupture of the water sac A live fetus
Exclusion criteria
Exclusion criteria: The presence of any other infection in the mother that requires antibiotic therapy Fetal congenital anomaly Delivery within 24 hours after receiving antibiotics Hypersensitivity to ampicillin, erythromycin, or azithromycin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical chorioamnionitis. Timepoint: Before the start of the intervention, After the start of the intervention until the time the fetus is completely removed from the uterus. Method of measurement: Fever above 38 degrees Celsius, Fetal Tachycardia, Maternal Tachycardia above 100 beats per minute, Increased WBC Count in the mother's serum to more than 15000 c/mm, or Discharge of purulent fluid from the vagina. | — |
Secondary
| Measure | Time frame |
|---|---|
| The period of delay until the childbirth. Timepoint: Every hour until the time of delivery of the fetus. Method of measurement: The elapsed time from the rupture of the water sac to the childbirth of the fetus in hours. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAtena Alavi
Zanjan University of Medical Sciences
Outcome results
None listed