Comparison of the effect of two tranquilizer oral drugs alprazolam and clonidin on patient,s anxiety before surgery and blood pressure and heart rate before induction of general anesthesia

Comparing the effect of clonidine with alprazolam on preoperative anxiety and hemodynamic variables in female patients candidates for abdominal surgery

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240511061740N1

Enrollment

Registered

2025-01-13

Start date

2024-08-22

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The effect of drug type on anxiety before induction of anesthesia.

Interventions

Intervention 1: Intervention group: Patients in the first group are given oral alprazolam (0.5 mg) the night before surgery. Intervention 2: Intervention group: Patients in the second group are given

Eligibility

Sex/Gender

Female

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Includes all female 18-60 years candidates for abdominal surgery referred to Shahid Sadoughi Hospital in Yazd

Exclusion criteria

Exclusion criteria: Existence of moderate to severe systemic disease history of using of sedative or tranquilizer drugs history of addiction to opioids or any sedative or psychotropic drugs patient disagreement for cooperation in this study

Design outcomes

Primary

Measure	Time frame
Anxiety score. Timepoint: Before administration of study drug and before induction of anesthesia. Method of measurement: VAS(0-10).;Systolic blood pressure. Timepoint: Before administration of study drug and before induction of anesthesia. Method of measurement: using monitoring device.;Diastolic blood pressure. Timepoint: Before administration of study drug and before induction of anesthesia. Method of measurement: using monitoring device.;Mean arterial pressure. Timepoint: Before administration of study drug and before induction of anesthesia. Method of measurement: using monitoring device.;Heart rate. Timepoint: Before administration of study drug and before induction of anesthesia. Method of measurement: using monitoring device.	—

Measure

Time frame

Anxiety score. Timepoint: Before administration of study drug and before induction of anesthesia. Method of measurement: VAS(0-10).;Systolic blood pressure. Timepoint: Before administration of study drug and before induction of anesthesia. Method of measurement: using monitoring device.;Diastolic blood pressure. Timepoint: Before administration of study drug and before induction of anesthesia. Method of measurement: using monitoring device.;Mean arterial pressure. Timepoint: Before administration of study drug and before induction of anesthesia. Method of measurement: using monitoring device.;Heart rate. Timepoint: Before administration of study drug and before induction of anesthesia. Method of measurement: using monitoring device.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.shokoofeh behdad

Yazd University of Medical Sciences

drbehdad@ssu.ac.ir+98 35 3822 1386

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026