Dry eye in GVHD disease. Complications of bone marrow transplant
Conditions
Interventions
Intervention 1: Intervention group: First, exosomes isolated from umbilical cord Wharton's jelly mesenchymal stem cells are isolated and stored in phosphate buffered saline (PBS) in a freezer. After a
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: Patients between 30-60 years old who have dry eyes and have been clinically and serologically diagnosed with GVHD by an ophthalmologist and hematologist Patients in whom the previous use of artificial tears could not relieve the symptoms of dry eyes Patients who have symptoms of eye redness, dryness, burning sensation, foreign body sensation, eye surface discomfort or visual fatigue in at least one eye Patients whose tear secretion test in both eyes is = 10 mm / 5 minutes and tear break time is less than 10 seconds and the degree of corneal fluorescein staining is more than 4.
Exclusion criteria
Exclusion criteria: People who are allergic to any medicine Pregnant or lactating women Patients with active fungal, bacterial or viral keratitis or conjunctivitis People who have serious heart, lung, liver or kidney or systemic diseases Patients who have incurable eye diseases before the study; Such as glaucoma, uveitis People who use contact lenses and do not want to remove them in the study People who have had eye surgery (including cataract surgery) in the last three months People who have simultaneously enrolled in other interventional clinical studies People who have used eye drops that may affect the clinical study in the last 24 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tear secretion is measured using the Schirmer test, which measures the amount of wetting of filter paper. Timepoint: Measurements are taken before the start of treatment and after 12 weeks. Method of measurement: Filter paper is placed next to the eye and the amount of wetting by tears is reported in millimeters. | — |
Secondary
| Measure | Time frame |
|---|---|
| The amount of change in the height of the tear meniscus is measured. Timepoint: Measurements are taken before the start of treatment and after 12 weeks. Method of measurement: Imaging is performed with a slit lamp device.;The detection of foreign bodies in the eye is measured using fluorescein orange and blue light. Timepoint: Measurements are taken before the start of treatment and after 12 weeks. Method of measurement: Number. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNegar Azarpira
Shiraz University of Medical Sciences
Outcome results
None listed