Helicobacter Pylori Infection. Helicobacter pylori [H.pylori] as the cause of diseases
Conditions
Interventions
Intervention 1: First intervention group: Patients in this group receive amoxicillin capsules (Farabi Company) 1 gram half an hour after breakfast, lunch and dinner
bismuth subcitrate tablets (Pursina Company) 240 mg half an hour before breakfast, lunch and dinner
and esomeprazole capsules (Abidi Company) 40 mg half an hour before breakfast and dinner for 14 days. Intervention 2: Second intervention group: Patients in this group receive amoxicillin capsules (Fa
and esomeprazole capsules (Abidi Company) 40 mg half an hour before breakfast and dinner for 14 days.
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Subjects with dyspepsia who undergo endoscopy Biopsy during endoscopy confirms the presence of Helicobacter pylori For the first time, a Helicobacter pylori eradication regimen is prescribed for them.
Exclusion criteria
Exclusion criteria: Unwillingness to participate in the study Patients who are taking anticoagulants, corticosteroids or ketoconazole at the same time Patients who have a history of stomach surgery Patients who have a history of heart failure, lung disease, chronic kidney failure, liver disease (cirrhosis or chronic hepatitis for any reason) or a history of cancer Consumption of alcoholic beverages in any amount The presence of any type of malignancy History of drug sensitivity to the drugs of this study History of H. pylori eradication regimens at any time Pregnancy and breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Helicobacter pylori eradication rate in treatment groups. Timepoint: 4 weeks after completion of treatment. Method of measurement: Stool Helicobacter Pylori Antigen. | — |
Secondary
| Measure | Time frame |
|---|---|
| Drug compliance rate in treatment groups. Timepoint: Fifteenth day from the start of treatment. Method of measurement: The medication bag is checked and if more than 90% of the medication has been consumed, it is considered excellent acceptance.;Side effects in treatment groups. Timepoint: If during treatment (14 days) there are severe complications (drug complications prevent daily life), the patient will make a phone call to the clinical caregiver. If there are no severe complications, the patient will be visited on day 15 and complications will be assessed. Method of measurement: Phone calls and visit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMasoud Hosseini
Mazandaran University of Medical Sciences
Outcome results
None listed