Effect of Tacrolimus in treatment of Recurrent Implantation Failure

Comparing the Effectiveness of Tacrolimus and the lack of Drug Treatment in Pregnancy Rate of Patients with Recurrent Implantation Failure

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240429061583N1

Enrollment

162

Registered

2024-05-10

Start date

2024-04-30

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Recurrent Implantation Failure.

Interventions

Intervention 1: Intervention group: Tacrolimus is taken at a dose of 0.5 mg twice a day, starting two days before the Embryo Transfer, for 16 days. Intervention 2: Control group: without medicine.

Eligibility

Sex/Gender

Female

Age

20 Years to 39 Years

Inclusion criteria

Inclusion criteria: Unexplained RIF History of Three or more Failed Embryo Transfers

Exclusion criteria

Exclusion criteria: Patients who Used Immunosuppressive Drugs Chronic Endometritis Uterine Anomaly Active Viral Diseases, Tuberculosis, Invasive Fungal Infections and Bacterial Infections Patients with High Blood Pressure, Renal Failure, liver Disorder, Heart Failure, Ischemic Heart Disease , Arrhythmia, Untreated Endocrine Disorder Immunocompromised Patients Patients with Malignant Tumors Patients with a history of Organ Transplantation Patients with a history of Tacrolimus Allergy Patients with a history of Blood Disorders, Coagulopathy Antiphospholipid Syndrome and Collagen Vascular Disease Patients receiving Potassium-Sparing Diuretics Patients who received Live Vaccine 2 months before admission

Design outcomes

Primary

Measure	Time frame
Chemical pregnancy Rate. Timepoint: Day 14 and 16 after embryo transfer. Method of measurement: level of serum ßHCG.;Clinical Pregnancy Rate. Timepoint: 4 to 5 Weeks after Embryo Transfer. Method of measurement: ultrasound and Observe at least one Gestational Sac.	—

Secondary

Measure	Time frame
Ongoing Pregnancy Rate. Timepoint: 12 Weeks after Embryo Transfer. Method of measurement: Normal Pregnancy with Fetal Heartbeat in ultrasound.;Abortion Rate. Timepoint: 12 Weeks after Embryo Transfer. Method of measurement: Excretion of Pregnancy Products or Failure to see Fetal Heart in Ultrasound at the end of 12 Weeks.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSoheila Arefi

Iranian academic center for education culture and research

nasehi-n@ajums.ac.ir+98 21 23519

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026