Comparison of the efficacy of a single dose of gonadotropin-releasing hormone agonist with its divided dose on the results of intracytoplasmic injection of sperm

Comparison of the efficacy of single vs. divided dose of gonadotropin-releasing hormone agonist (GNRHa) as a trigger in overresponding patients undergoing intracytoplasmic sperm injection (ICSI)

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240426061578N1

Enrollment

122

Registered

2024-05-28

Start date

2024-06-09

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Female infertility

Interventions

Intervention 1: Intervention group A - Trigger method of group A: two ampoules of Deca Peptide (0.1) are injected 36 hours before the puncture and the second dose is injected 24 hours after the first

Eligibility

Sex/Gender

Female

Age

20 Years to 39 Years

Inclusion criteria

Inclusion criteria: More or equal to 15 follicles above 11 mm per trigger day Indication for intracytoplasmic sperm injection (ICSI ) Body mass index 18-30 The presence of any two ovaries

Exclusion criteria

Exclusion criteria: Cycles stimulated with human chorionic gonadotropin (HCG) Donation cycles using GNRH stimulation Severe male factor with sperm count below 2 million Patients with hypogonadism Uterine abnormalities

Design outcomes

Primary

Measure	Time frame
Number of high quality embryos. Timepoint: 2 days after conception. Method of measurement: Embryology laboratory.	—

Secondary

Measure	Time frame
Fertility rate. Timepoint: 7 days after ICSI. Method of measurement: Embryology report.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSoheila Ansaripoor

Avicenna Infertility Clinic

Soh.ansaripoor@gmail.com+98 21 23519

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026