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Progesterone in luteal phase support in patients undergoing embryo transfer cycle

A Comparison of Oral Dydrogesterone with Vaginal and Intramuscular Progesterone for Luteal Phase Support in In vitro Fertilization

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240421061550N1
Enrollment
30
Registered
2024-08-01
Start date
2024-07-06
Completion date
Unknown
Last updated
2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Female infertility

Interventions

Intervention 1: Control group one (group A)
10 people received 50 mg of intramuscular progesterone ampoule once a day/ Fertigest ampoule, Aburihan Company, Iran/50 mg). Intervention 2: Control group two (C) includes 10 people who received 400 m
Actoverco pharmaceutical company, Iran. Intervention 3: Intervention group: one is the B group in which 10 people received oral dydrogesterone 40 (Dofamed) mg per day
Atipharmed Company, Iran.

Sponsors

Research Vice President of Imam Khomeini Hospital Complex - Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Age between 20 and 40 years Women with normal endometrial thickness (8 mm or more) in the stage of endometrial preparation Body mass index below 30 kilograms per square meter FSH less than 15 Having less than 3 times entering the ART cycle Not having structural problems of the uterus (normal anatomy)

Exclusion criteria

Exclusion criteria: Having intrauterine pathologies such as polyps or submucosal myoma Intramural myoma above 3 cm Stage 3 or 4 endometriosis Untreated hydrosalpinx History of ovarian hyperstimulation syndrome Those who are candidates for embryo donation Genital Tuberculosis

Design outcomes

Primary

MeasureTime frame
The primary outcome is clinical pregnancy rateand the continuation of pregnancy until 12 weeks. Timepoint: The presence of fetal heart rate in 6-7 weeks and continued pregnancy up to 12 weeks. Method of measurement: With transvaginal ultrasound.

Secondary

MeasureTime frame
Secondary outcomes of chemical pregnancy rate. Timepoint: Positive BHCG level after two weeks of embryo transfer and a questionnaire filled by the therapist asking the patient. Method of measurement: Laboratory BHCG serum test and Questionnaire.;Abortion rate. Timepoint: BHCG level , transvaginal ultrasound and a questionnaire filled by the therapist asking the patient. Method of measurement: Laboratory BHCG serum test and questionnaire.;Ectopic pregnancy rate. Timepoint: Transvaginal ultrasound and a questionnaire filled by the therapist asking the patient. Method of measurement: Transvaginal ultrasound and questionnaire.;Presence of drugs complications such as drug sensitivity / vaginal burning and itching / muscle pain at the injection site / vaginal bleeding..etc..). Timepoint: A questionnaire filled by the therapist asking the patient after using the drugs. Method of measurement: Questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHawraa Shbeeb

Tehran University of Medical Sciences

Princesshawraa8@gmail.com+98 936 113 7440

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026