The effect of premedication with an antidepressant before surgery of impacted mandibular third molar on pain control

The effect of premedication with amitriptyline on pain control of patients after surgery of impacted mandibular third molar

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240419061526N1

Enrollment

Registered

2024-05-05

Start date

2024-06-22

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Impaction of mandibular third molar.

Interventions

Intervention 1: Intervention group: Patients receive a 25 mg dose of amitriptyline 1 hour before surgery. Intervention 2: Control group: Patients receive a placebo 1 hour before surgery.

Eligibility

Sex/Gender

All

Age

18 Years to 25 Years

Inclusion criteria

Inclusion criteria: Participants with similar impacted third mandibular molars on both left and right sides with similar impaction pattern Participants with informed consent to participate in the study Participants with no inflammatory symptoms in the oral cavity such as tooth decay and advanced periodontal diseases

Exclusion criteria

Exclusion criteria: Participants who are unwilling to participate in the study Pregnancy Taking pain-relieving drugs two weeks before surgery Allergy to amitriptyline Systemic disorders that are contraindications for surgery, such as high blood pressure and uncontrolled diabetes

Design outcomes

Primary

Measure	Time frame
Pain intensity of patients after surgery. Timepoint: Measuring the pain level of patients every 6 hours after surgery up to 24 hours. Method of measurement: Visual Analogue Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammadhosein Asadi

Tabriz University of Medical Sciences

hhjdentist@gmail.com+98 41 3544 5152

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026