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The effect of endurance training and consumption of antioxidant vitamins on disease progression in patients with CVD

The effects of eight weeks aerobic training and vitamin E & C prescription on plasma levels of MMPS and their tissue inhibitor(TIM1) in patients with CAD

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240418061518N1
Enrollment
60
Registered
2024-05-25
Start date
2024-05-21
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary artery diseases. Atherosclerotic heart disease of native coronary artery

Interventions

Intervention 1: Intervention group: First group: eight weeks of aerobic training, second group: eight weeks of vitamin E and C supplements(1000 mg of D-Alpha Tocopherol Tablets by Life Plan Company pe

Sponsors

Islamic Azad University, Rasht Branch
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Subjects have coronary artery disease (with the condition of at least 50% narrowing of at least two main coronary arteries), which has been confirmed by cardiologists based on examinations, complete blood tests, echocardiography, exercise stress test and angiography.

Exclusion criteria

Exclusion criteria: using of drugs or other antioxidant supplements other than the supplements considered in this research

Design outcomes

Primary

MeasureTime frame
Matrix Metalloproteinases 1? 2? 3 and 9. Timepoint: beginning and end of the eight-week experimental period. Method of measurement: Sampling of venous blood.;Tissue inhibitor of Matrix Metalloproteinases 1. Timepoint: beginning and end of the eight-week experimental period. Method of measurement: Sampling of venous blood.

Secondary

MeasureTime frame
Heart rate of subjects during exercise training. Timepoint: At the beginning, during and at the end of each exercise training session. Method of measurement: Using the cardiac monitoring device with the subjects.;Systolic and diastolic blood pressure of subjects during exercise. Timepoint: At the beginning and at the end of each exercise training session. Method of measurement: Using an analog blood pressure monitor.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahdi Rezagholizadeh

Islamic Azad University, Zanjan Branch

mahdi.reza@iau.ac.ir+98 24 3345 5969

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026