infertility. Female infertility, unspecified
Conditions
Interventions
Intervention 1: Intervention group: Melatonin will be prescribed for two months in the form of 6 mg every night from the beginning of the cycle of the month before IUI to the end of the IUI cycle. Int
Sponsors
Yasouj University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 42 Years
Inclusion criteria
Inclusion criteria: Absence of uterine and tubal anomalies in women and absence of genital anomalies and varicocele in men. Absence of underlying disease in couples Absence of smoking, tobacco, drugs and alcohol in couples Body mass index (BMI) less than 35 in women Normal sperm analysis Normal hysterosalpingography (HSG) of the lady Ovary storage suitable for women Not taking antioxidant drugs
Exclusion criteria
Exclusion criteria: Cause a complication during the study for the patient Unwillingness to continue cooperation of the patient
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1- Determination and comparison of the amount of TNF-a in infertile couples with an unknown cause receiving melatonin supplementation compared to the control group before and after the study 2- Determination and comparison of the CRP level in infertile couples with an unknown cause receiving melatonin supplementation compared to the group Control before and after the study 3- Determine and compare the level of SOD activity in infertile couples with an unknown cause receiving melatonin supplements compared to the control group before and after the study 4- Determine and compare the level of CAT activity in infertile couples with an unknown cause receiving Melatonin supplementation compared to the control group before and after the study 5- Determining and comparing the level of GPX activity in infertile couples with an unknown cause receiving melatonin supplementation compared to the control group before and after the study 6- Determining and comparing the MDA level in infertile couples with an unknown cause receiving melatonin supplements compared to the control group before and after the study.7- Determining and comparing the amount of protein carbonyl (PCO) in infertile couples with an unknown cause receiving melatonin supplements compared to the control group before and after the study.8- Determining and comparing the total antioxidant capacity of plasma (FRAP) in infertile couples with an unknown cause receiving melatonin supplements compared to the control group before and after the study.9- Determining and comparing the amount of nitric oxide (NO) metabolites in infertile couples with an unknown cause receiving melatonin supplements compared to the control group before and after the study. 10- Determining and comparing the amount of melatonin in infertile couples with an unknown cause receiving melatonin supplements compared to the control group before and after the study.11- Determining the rate of pregnancy success after IUI in infertile couples with an unkn | — |
Secondary
| Measure | Time frame |
|---|---|
| Determining the rate of pregnancy success after IUI in infertile couples with an unknown cause receiving melatonin supplements compared to the control group. Timepoint: After completing the study. Method of measurement: bhcg measurement, vaginal sonography at 7 weeks, no pregnancy loss until 20 weeks. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNastaran Golmohamadi
Yasouj University of Medical Sciences
Outcome results
None listed