Effect of probiotic bacteria on decreasing seizures in children with refractory epilepsy

Effect of GABA-producing probiotic bacteria on decreasing seizures in children with refractory epilepsy

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240408061452N1

Enrollment

Registered

2024-05-09

Start date

2024-04-20

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

refractory or drug-resistant epilepsy. Epilepsy, unspecified

Interventions

Intervention 1: The group receiving routine treatment along with a selected probiotic, chosen from strains of Lactobacillus brevis, Lactobacillus delbrueckii subsp. bulgaricus, and Lactobacillus plant

Eligibility

Sex/Gender

All

Age

4 Years to 16 Years

Inclusion criteria

Inclusion criteria: Patients known as drug-resistant epilepsy having seizures despite taking more than two appropriate medications for the type of seizure age between 4 to 16 years

Exclusion criteria

Exclusion criteria: The cause of the seizure may be progressive brain diseases. digestive disorders which interfere probiotic absorption incidence of complications including diarrhea, vomiting, rash The patient's reluctance to continue participating in the study.

Design outcomes

Primary

Measure	Time frame
Seizure frequency. Timepoint: 30 days. Method of measurement: numbering seizure frequency.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShima shekari

Mashhad University of Medical Sciences

dr.shekari.shima@gmail.com+98 51 3841 1538

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026