Obstructive Sleep Apnea. Obstructive sleep apnea (adult) (pediatric)
Conditions
Interventions
Intervention 1: Intervention group: Patients are treated with Nortriptyline 25 mg for one month, and then undergo polysomnography. Intervention 2: Control group: Patients are treated with a placebo f
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: =18 years of age at the time of informed consent PSG criteria: AHI of >5; = 25% central or mixed apneas; and PLM arousal index =15 Escale of sleepiness symptom score =10 PAP intolerance or current PAP refusal BMI between 18.5 and 30 kg/m2 for men, or 32 kg/m2 for women
Exclusion criteria
Exclusion criteria: Narcolepsy, restless leg syndrome, REM sleep behavior disorder Insomnia disorder or use of sedative-hypnotics or other medication to treat or avoid insomnia symptoms, shift disorder or night shift craniofacial malformation syndrome, or grade =3 tonsillar hypertrophy Clinically significant cardiac disease, e.g., ventricular arrhythmia, untreated or unstable coronary artery disease, cardiac failure Metabolic, renal, pulmonary disease, and uncontrolled HTN Neuromuscular disorder (e.g., motor neuron disease, muscular dystrophy or myopathy, myasthenic syndrome); epilepsy; Parkinson's, Alzheimer's, or another neurodegenerative disease Central neural system stimulant or suppressant drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Apnea-Hypopnea Index. Timepoint: after one month of medication consumption. Method of measurement: Polysomnography.;Sleepiness Scale. Timepoint: after one month of medication consumption. Method of measurement: Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFateme Mohammadi
Shahid Beheshti University of Medical Sciences
Outcome results
None listed